{"id":"W2002122436","doi":"10.1016/j.aquatox.2005.03.014","title":"Identification of a multixenobiotic resistance mechanism in primary cultured epidermal cells from Oncorhynchus mykiss and the effects of environmental complex mixtures on its activity","year":2005,"lang":"en","type":"article","venue":"Aquatic Toxicology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Technological University Dublin","keywords":"Biology; Efflux; P-glycoprotein; Epidermis (zoology); Xenobiotic; Cell biology; ATP-binding cassette transporter; Biochemistry; Molecular biology; Transporter; Multiple drug resistance; Microbiology; Gene; Drug resistance; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008844045,0.000177253,0.000214736,0.0001915615,0.000190213,0.0002537748,0.0001290602,0.0002211058,0.0006752856],"category_scores_gemma":[0.00008004815,0.0001214535,0.0002187033,0.0001140879,0.0001574888,0.0001954373,0.000180828,0.0003511151,0.0002073077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002404326,"about_ca_system_score_gemma":0.0002226476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00354465,"about_ca_topic_score_gemma":0.004447505,"domain_scores_codex":[0.9999338,0.000007166292,0.000008486985,0.00001843113,0.0000151873,0.00001690456],"domain_scores_gemma":[0.9999053,0.00002165046,0.00001693463,0.00001611795,0.00001945106,0.00002053758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002120755,0.000004261234,0.0002435058,0.000006640918,0.000001345327,0.00001454277,0.000006153236,0.000005398755,0.9995137,0.000008838801,0.0000037025,0.0001706829],"study_design_scores_gemma":[0.000006344514,0.000320058,0.06087024,0.000003523755,0.00002703934,0.0002627245,0.00012388,0.0003195657,0.9369823,0.00003075158,0.001047931,0.00000551243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997499,0.000550884,0.0007044577,0.00004240725,0.000009626674,0.00001851996,0.0003785055,0.00001527319,0.0007812594],"genre_scores_gemma":[0.9953659,0.0003625464,0.0009758152,0.00003112731,0.000004973677,0.00001849375,0.0008104325,0.000008463053,0.002422293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00354465,"threshold_uncertainty_score":0.00704807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009127729355564277,"score_gpt":0.234357435889774,"score_spread":0.2252297065342097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}