{"id":"W2002139658","doi":"10.1093/toxsci/kfs292","title":"Exposure to Valproic Acid Inhibits Chondrogenesis and Osteogenesis in Mid-Organogenesis Mouse Limbs","year":2012,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Chondrogenesis; Limb bud; Valproic Acid; Histone deacetylase; RUNX2; Teratology; SOX9; Chemistry; Neural tube; Cell biology; Developmental toxicity; Limb development; Endocrinology; Internal medicine; Biology; Embryo; Gene expression; Osteoblast; Biochemistry; In vitro; Histone; Medicine; Mesenchymal stem cell; Neuroscience; Fetus; Gene; Genetics; Pregnancy; Epilepsy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386374,0.0003186289,0.0002927534,0.000390143,0.0001483395,0.0002752886,0.0001883648,0.0002396784,0.000967425],"category_scores_gemma":[0.0001207241,0.0002373289,0.0002776037,0.0001368085,0.0002504369,0.0001285023,0.0001483269,0.0005542556,0.0002547841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002776119,"about_ca_system_score_gemma":0.0002952306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008969633,"about_ca_topic_score_gemma":0.001809376,"domain_scores_codex":[0.9997961,0.0000447653,0.00002547691,0.00003632885,0.00004667222,0.0000506613],"domain_scores_gemma":[0.999855,0.00002631664,0.00003804523,0.00001728793,0.00001297743,0.00005033799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001688021,0.00002069398,0.0001948285,0.000017471,0.000004680041,0.0000275262,0.000009750443,0.00002963377,0.9988921,0.00003403303,0.00001616322,0.0005843181],"study_design_scores_gemma":[0.00001140148,0.0004332752,0.003506266,0.000004127422,0.00001277381,0.0000749417,0.00001957966,0.0001947306,0.9949605,0.00002587351,0.0007543731,0.000002016508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948642,0.002242483,0.001006093,0.00008181842,0.00002589754,0.00001501126,0.0003695666,0.00005104357,0.001344104],"genre_scores_gemma":[0.9933164,0.001625682,0.0009857827,0.00004468184,0.000009379642,0.00003510919,0.0004393459,0.00001911076,0.003524589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000967425,"threshold_uncertainty_score":0.003236294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02927035697280162,"score_gpt":0.3011975313199304,"score_spread":0.2719271743471288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}