{"id":"W2002139658","doi":"10.1093/toxsci/kfs292","title":"Exposure to Valproic Acid Inhibits Chondrogenesis and Osteogenesis in Mid-Organogenesis Mouse Limbs","year":2012,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Chondrogenesis; Limb bud; Valproic Acid; Histone deacetylase; RUNX2; Teratology; SOX9; Chemistry; Neural tube; Cell biology; Developmental toxicity; Limb development; Endocrinology; Internal medicine; Biology; Embryo; Gene expression; Osteoblast; Biochemistry; In vitro; Histone; Medicine; Mesenchymal stem cell; Neuroscience; Fetus; Gene; Genetics; Pregnancy; Epilepsy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001018072,0.0002145213,0.000230099,0.0001674395,0.0002401365,0.00005418785,0.0003846136,0.0002570402,0.0001312215],"category_scores_gemma":[0.0005285783,0.0001691956,0.00006520007,0.0007154209,0.000403623,0.00001954607,0.000428344,0.0000938005,0.00008114603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005331482,"about_ca_system_score_gemma":0.00008639077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003429386,"about_ca_topic_score_gemma":0.0001790402,"domain_scores_codex":[0.9976934,0.0002171065,0.0002751092,0.0006227041,0.0003863417,0.0008054074],"domain_scores_gemma":[0.999158,0.00004563349,0.00004885836,0.0002449171,0.00005008452,0.0004524887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004474967,0.0002316239,0.03120695,0.000007917123,0.000005344743,0.000003365106,0.0000994969,0.00002784761,0.964258,0.00001736359,0.0002971425,0.003800248],"study_design_scores_gemma":[0.0002479709,0.001254247,0.01507295,0.000007067087,0.000004894787,0.00002505649,0.000145675,0.000003078531,0.9795639,0.000007323584,0.00341584,0.0002520138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956375,0.002805308,0.00002606695,0.0006024327,0.0001161158,0.0003595695,0.0000149685,0.00002245565,0.0004155609],"genre_scores_gemma":[0.9973087,0.0001535683,0.00119687,0.0004725138,0.0002161542,0.000101599,0.000007383553,0.00001497393,0.0005282129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.016134,"threshold_uncertainty_score":0.6899598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02927035697280162,"score_gpt":0.3011975313199304,"score_spread":0.2719271743471288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}