{"id":"W2002151843","doi":"10.1159/000280586","title":"The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog <i>Silurana tropicalis</i>","year":2009,"lang":"en","type":"article","venue":"Sexual Development","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada; Ontario Genomics; Health Canada; University of Ottawa","funders":"Novartis Pharma; University of Ottawa; Novartis","keywords":"Biology; Endocrinology; Internal medicine; Aromatase; DIO2; Iodothyronine deiodinase; Aromatase inhibitor; Deiodinase; Hormone; Genetics; Triiodothyronine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004698979,0.0002251189,0.0001615612,0.0001665506,0.0001654864,0.0001730247,0.0001282631,0.0001467398,0.001631857],"category_scores_gemma":[0.00004964418,0.000132343,0.0002320191,0.0001210412,0.0001677498,0.000126844,0.00008315317,0.0003063692,0.0002118597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002292681,"about_ca_system_score_gemma":0.0001758745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00305531,"about_ca_topic_score_gemma":0.006382986,"domain_scores_codex":[0.999949,0.000006022525,0.000003999726,0.00001480584,0.00001124092,0.00001490642],"domain_scores_gemma":[0.9999454,0.000004728678,0.00002081765,0.00000270291,0.000006193055,0.00002008263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002207474,0.0000237834,0.0004962796,0.00003246571,0.000006877439,0.00003657563,0.00002008682,0.00002595308,0.9976454,0.00003716416,0.00003248693,0.001422114],"study_design_scores_gemma":[0.00004297845,0.00213527,0.05744182,0.000010981,0.00007324036,0.000301875,0.0001794643,0.0003486769,0.9346999,0.00003316635,0.004721525,0.00001111861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968107,0.001189047,0.0002663869,0.00005282522,0.00001067847,0.000009190499,0.0002803955,0.00002730878,0.001353406],"genre_scores_gemma":[0.9929578,0.0008370043,0.00063456,0.00005783464,0.000006966074,0.00002225554,0.0004585469,0.000009879942,0.005015148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00305531,"threshold_uncertainty_score":0.006075025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008064442412194804,"score_gpt":0.2307314360431002,"score_spread":0.2226669936309054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}