{"id":"W2002151843","doi":"10.1159/000280586","title":"The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog <i>Silurana tropicalis</i>","year":2009,"lang":"en","type":"article","venue":"Sexual Development","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada; Ontario Genomics; Health Canada; University of Ottawa","funders":"Novartis Pharma; University of Ottawa; Novartis","keywords":"Biology; Endocrinology; Internal medicine; Aromatase; DIO2; Iodothyronine deiodinase; Aromatase inhibitor; Deiodinase; Hormone; Genetics; Triiodothyronine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003590779,0.0002016602,0.0001672044,0.00002215681,0.0003854703,0.0001258677,0.000201954,0.0001026754,0.000006477571],"category_scores_gemma":[0.00008654579,0.0001025953,0.00003534041,0.00005621856,0.000239787,0.00001080093,0.000127154,0.000108513,0.000003211428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001270074,"about_ca_system_score_gemma":0.00005178296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002920526,"about_ca_topic_score_gemma":0.00008268579,"domain_scores_codex":[0.9985976,0.000213359,0.0003725575,0.0003160624,0.0002494815,0.0002509159],"domain_scores_gemma":[0.9994544,0.00009870402,0.0001008509,0.000237112,0.0000343211,0.00007455127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000812944,0.0002814368,0.0006767896,0.00004004458,0.00004963873,0.00001683364,0.00231031,0.000006231448,0.9308601,0.0007434726,0.004524951,0.05967722],"study_design_scores_gemma":[0.007068051,0.00116569,0.354318,0.00009606797,0.00005856765,0.0001114587,0.002681191,0.0001549661,0.5401506,0.0012358,0.09217872,0.0007808821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954683,0.001869162,0.00008087575,0.00192877,0.0001348848,0.0003693143,0.00002018723,0.000008113749,0.0001203843],"genre_scores_gemma":[0.9978385,0.0002876975,0.0003037918,0.0006386149,0.0002193075,0.00005830818,0.0001596516,0.000008106695,0.0004859976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3907095,"threshold_uncertainty_score":0.4183717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008064442412194804,"score_gpt":0.2307314360431002,"score_spread":0.2226669936309054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}