{"id":"W2002165983","doi":"10.1089/zeb.2012.0832","title":"Evaluating the Mutagenic Activity of Targeted Endonucleases Containing a <i>Sharkey</i> FokI Cleavage Domain Variant in Zebrafish","year":2013,"lang":"en","type":"article","venue":"Zebrafish","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"","keywords":"Transcription activator-like effector nuclease; Zinc finger nuclease; Nuclease; Biology; Genome editing; FokI; Mutagenesis; Genetics; DNA; Cell biology; Genome; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005335508,0.0002092117,0.0002514979,0.00005440876,0.00008039063,0.00004456337,0.000315536,0.0001337567,0.0001315398],"category_scores_gemma":[0.0002900097,0.000176829,0.0001327878,0.0001800701,0.00007748454,0.000013137,0.0001931167,0.0001848202,0.0000112268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001837218,"about_ca_system_score_gemma":0.00006413968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003015322,"about_ca_topic_score_gemma":0.0001167315,"domain_scores_codex":[0.9985272,0.0001662872,0.0003331826,0.0003727941,0.0002060102,0.0003944743],"domain_scores_gemma":[0.9991512,0.00008717149,0.0001314068,0.0004835383,0.00006693526,0.00007969966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008512132,0.00007274915,0.0008089435,0.00002971134,0.0000586466,0.000007486507,0.0002548721,0.0003638833,0.9917244,0.00004042155,0.001022419,0.005531391],"study_design_scores_gemma":[0.0023079,0.0009310243,0.06984418,0.0000796663,0.00004754252,0.00005895331,0.0005882094,0.003551744,0.9194281,0.000318946,0.002339222,0.0005045108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955574,0.0004661754,0.001433088,0.0001863473,0.0001325938,0.0005055211,0.00002162006,0.00002265685,0.001674649],"genre_scores_gemma":[0.998279,0.00002426685,0.00102187,0.000311408,0.0001378101,0.00008751179,0.0000274708,0.0000388083,0.00007181454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07229625,"threshold_uncertainty_score":0.7210878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0146469285632691,"score_gpt":0.3009226556525824,"score_spread":0.2862757270893133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}