{"id":"W2002175782","doi":"10.1007/s00280-012-2001-0","title":"Effect of abiraterone acetate plus prednisone on the pharmacokinetics of dextromethorphan and theophylline in patients with metastatic castration-resistant prostate cancer","year":2012,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; European Commission","keywords":"Abiraterone acetate; Pharmacokinetics; Prednisone; Theophylline; Pharmacology; Medicine; Dextromethorphan; Prostate cancer; Bioequivalence; Internal medicine; Cancer; Androgen deprivation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009244045,0.0007273011,0.002112767,0.0003840748,0.000518339,0.0009065804,0.0005014373,0.0006402798,0.001298432],"category_scores_gemma":[0.005420693,0.0005011807,0.001027579,0.0006077822,0.0006530872,0.001190655,0.0003116472,0.002799151,0.0003282521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008741919,"about_ca_system_score_gemma":0.001570914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002805124,"about_ca_topic_score_gemma":0.00548054,"domain_scores_codex":[0.9991311,0.0004754311,0.00006013117,0.0001026671,0.0001103562,0.0001202131],"domain_scores_gemma":[0.9977468,0.0008934753,0.0003660694,0.0001506486,0.00007097315,0.0007720399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8094247,0.005169344,0.03531371,0.0002593987,0.001313039,0.001077029,0.0006218559,0.005435878,0.03307221,0.0002964224,0.001541557,0.1064749],"study_design_scores_gemma":[0.1110732,0.390356,0.4273918,0.0001351495,0.00381417,0.00451319,0.0008997197,0.02003156,0.02983781,0.001067384,0.01053887,0.0003411966],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962041,0.001931098,0.0002121521,0.0003256008,0.0001086172,0.00005125373,0.0001847459,0.00006526209,0.000917207],"genre_scores_gemma":[0.9982741,0.0006013717,0.0002478119,0.0001022038,0.0001245037,0.00002128419,0.0001547316,0.00001928948,0.0004546614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002805124,"threshold_uncertainty_score":0.006342709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02044639979424636,"score_gpt":0.3537369429276789,"score_spread":0.3332905431334326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}