{"id":"W2002194982","doi":"10.4161/auto.22401","title":"Elevated MTORC1 signaling and impaired autophagy","year":2012,"lang":"en","type":"article","venue":"Autophagy","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Institute on Aging","keywords":"LMNA; Dilated cardiomyopathy; Biology; Lamin; Muscular dystrophy; Cardiomyopathy; Progeria; Nuclear lamina; Autophagy; mTORC1; Premature aging; Skeletal muscle; Cell biology; Genetics; Cancer research; Internal medicine; Endocrinology; Heart failure; Medicine; Gene; Signal transduction; PI3K/AKT/mTOR pathway; Nuclear protein; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001153484,0.0001239184,0.0001017195,0.00003014858,0.00008279956,0.00001887557,0.00006205909,0.0001406745,0.0001080025],"category_scores_gemma":[0.00003303129,0.0001133762,0.00004684169,0.00005834058,0.00004009936,0.00000839474,0.00005880158,0.00006711418,0.00003108759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008815429,"about_ca_system_score_gemma":0.00001688415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001540325,"about_ca_topic_score_gemma":0.000001887454,"domain_scores_codex":[0.9993088,0.00003396179,0.0001207506,0.0001899206,0.00007455206,0.0002720758],"domain_scores_gemma":[0.9996251,0.000007502874,0.0000446682,0.0001857073,0.0000283289,0.0001086683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003303008,0.00001891683,0.002047029,0.000008343191,0.00003539362,0.00000143539,0.00008168159,0.000005922953,0.9909995,0.0005833597,0.001022374,0.005163019],"study_design_scores_gemma":[0.0005542779,0.0002526843,0.04273953,0.000005822352,0.00003251723,0.00006501223,0.00004570621,0.0001056001,0.8676623,0.0001354822,0.08815656,0.0002444792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964969,0.001589288,0.0004632659,0.00002269188,0.000310993,0.00008198723,0.000003998451,0.00004058516,0.0009903262],"genre_scores_gemma":[0.9977043,0.00002966818,0.000508156,0.0003627127,0.0005962537,0.000005238104,0.00004549327,0.00002340005,0.0007248063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1233372,"threshold_uncertainty_score":0.4623348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007062028622860708,"score_gpt":0.2206199586251752,"score_spread":0.2135579300023145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}