{"id":"W2002194982","doi":"10.4161/auto.22401","title":"Elevated MTORC1 signaling and impaired autophagy","year":2012,"lang":"en","type":"article","venue":"Autophagy","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Institute on Aging","keywords":"LMNA; Dilated cardiomyopathy; Biology; Lamin; Muscular dystrophy; Cardiomyopathy; Progeria; Nuclear lamina; Autophagy; mTORC1; Premature aging; Skeletal muscle; Cell biology; Genetics; Cancer research; Internal medicine; Endocrinology; Heart failure; Medicine; Gene; Signal transduction; PI3K/AKT/mTOR pathway; Nuclear protein; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001819966,0.000467957,0.0004228772,0.0005969179,0.0002833212,0.000478248,0.0002890506,0.0009145967,0.001664578],"category_scores_gemma":[0.0001765802,0.0002334771,0.0003252361,0.0002912734,0.0007470872,0.0002537339,0.0004256833,0.0006451685,0.0003392502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004655739,"about_ca_system_score_gemma":0.0003524383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005103464,"about_ca_topic_score_gemma":0.0006681905,"domain_scores_codex":[0.9998059,0.00003522918,0.00002574704,0.00004851506,0.00004598437,0.00003862778],"domain_scores_gemma":[0.9998438,0.00001416332,0.00007158157,0.00001591461,0.000009827118,0.00004461431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003244667,0.0002441505,0.01646892,0.0002715901,0.000103869,0.01257062,0.00008427947,0.0003521605,0.9539668,0.002950627,0.001299368,0.008442944],"study_design_scores_gemma":[0.0004625399,0.001884287,0.2497764,0.00008618676,0.0002533977,0.09131204,0.0002925386,0.002072125,0.6342124,0.004693375,0.01488851,0.00006612758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909923,0.00372139,0.001117531,0.0006052192,0.00005241365,0.00001851642,0.0004220693,0.000102272,0.002968313],"genre_scores_gemma":[0.9963802,0.001202826,0.0005959114,0.0002046559,0.0000378185,0.00001960505,0.000284697,0.000008913091,0.001265468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001664578,"threshold_uncertainty_score":0.005568564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007062028622860708,"score_gpt":0.2206199586251752,"score_spread":0.2135579300023145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}