{"id":"W2002213586","doi":"10.1371/journal.pone.0008964","title":"GCN5 Is a Positive Regulator of Origins of DNA Replication in Saccharomyces cerevisiae","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Origin recognition complex; Biology; Control of chromosome duplication; DNA replication; DNA replication factor CDT1; Replication factor C; Chromatin; Pre-replication complex; Regulator; Saccharomyces cerevisiae; Genetics; Eukaryotic DNA replication; Histone; Origin of replication; Cell biology; DNA; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008516878,0.0006106624,0.0001702462,0.0002510968,0.000244332,0.0002832675,0.0002629752,0.0001858288,0.00124665],"category_scores_gemma":[0.0001312941,0.0001294957,0.0001734216,0.0001587391,0.0001466084,0.0001174291,0.0002931886,0.0002026839,0.0006469264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008015839,"about_ca_system_score_gemma":0.0002465049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003180881,"about_ca_topic_score_gemma":0.005118401,"domain_scores_codex":[0.9998931,0.0000105058,0.000008232251,0.00003459811,0.0000438311,0.000009730222],"domain_scores_gemma":[0.9999279,0.00000792963,0.00001788351,0.000009751667,0.0000106526,0.00002593752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001796374,0.00001450929,0.001552014,0.0001048886,0.00001066925,0.000250173,0.00001983255,0.0002877044,0.9897664,0.0003876792,0.0002522835,0.007174265],"study_design_scores_gemma":[0.00001673676,0.0001081178,0.01991564,0.00003568296,0.00004305561,0.0009440784,0.00005594946,0.003499192,0.9547698,0.0002986976,0.02029779,0.00001522817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687775,0.01131461,0.009497325,0.0002112848,0.0001868596,0.00003702233,0.002284632,0.0008310577,0.006859641],"genre_scores_gemma":[0.9868913,0.001329073,0.004116386,0.0000631128,0.000007463493,0.00001422942,0.002130712,0.00005372208,0.005393947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003180881,"threshold_uncertainty_score":0.006324768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01452438347710524,"score_gpt":0.2372482897190802,"score_spread":0.222723906241975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}