{"id":"W2002219838","doi":"10.1080/17482960802103107","title":"50bp deletion in the promoter for superoxide dismutase 1 (SOD1) reduces SOD1 expression in vitro and may correlate with increased age of onset of sporadic amyotrophic lateral sclerosis","year":2008,"lang":"en","type":"article","venue":"Amyotrophic Lateral Sclerosis","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Montréal; Hôpital Notre-Dame; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Neurological Disorders and Stroke","keywords":"SOD1; Biology; Amyotrophic lateral sclerosis; Promoter; Genetics; Gene; Molecular biology; Gene expression; Superoxide dismutase; Transcription factor; Medicine; Oxidative stress; Pathology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00101482,0.0006924939,0.001452285,0.0006824344,0.000246475,0.00006172209,0.000539494,0.0004392749,0.00008260123],"category_scores_gemma":[0.0001564376,0.0004497243,0.0002946761,0.001126694,0.001169441,0.0005440737,0.000202521,0.0008534318,0.000006598442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002522199,"about_ca_system_score_gemma":0.0002079203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00327491,"about_ca_topic_score_gemma":0.0001338292,"domain_scores_codex":[0.9945361,0.0006305615,0.001479214,0.001025745,0.001176098,0.001152284],"domain_scores_gemma":[0.9977156,0.0003412805,0.0004571268,0.0008767461,0.000253677,0.0003555889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008018132,0.0009415793,0.09759633,0.0003702875,0.0001023843,0.0003217207,0.002525679,0.00007693515,0.8884614,0.00001561678,0.0001076432,0.001462287],"study_design_scores_gemma":[0.008648808,0.001873049,0.9119352,0.002286147,0.0001385333,0.0002098286,0.00009845504,0.0007130601,0.07341078,0.0001641568,0.00003261269,0.0004893981],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949969,0.0003664478,0.00003751051,0.001590095,0.00007663504,0.002644708,0.000203471,0.00005641518,0.00002783187],"genre_scores_gemma":[0.9950682,0.001228858,0.002229737,0.0003149194,0.000110131,0.0004461801,0.0004112778,0.0001194024,0.00007131098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8150506,"threshold_uncertainty_score":0.9997954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0429651795959145,"score_gpt":0.2618163179855226,"score_spread":0.2188511383896081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}