{"id":"W2002219838","doi":"10.1080/17482960802103107","title":"50bp deletion in the promoter for superoxide dismutase 1 (SOD1) reduces SOD1 expression in vitro and may correlate with increased age of onset of sporadic amyotrophic lateral sclerosis","year":2008,"lang":"en","type":"article","venue":"Amyotrophic Lateral Sclerosis","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Montréal; Hôpital Notre-Dame; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Neurological Disorders and Stroke","keywords":"SOD1; Biology; Amyotrophic lateral sclerosis; Promoter; Genetics; Gene; Molecular biology; Gene expression; Superoxide dismutase; Transcription factor; Medicine; Oxidative stress; Pathology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002388781,0.0002249863,0.0001948683,0.0003570101,0.0001357755,0.0001727112,0.0001406634,0.0001664467,0.002100323],"category_scores_gemma":[0.0003891868,0.0001287586,0.0001549252,0.0001866784,0.0001663446,0.0000722917,0.0001405676,0.0002342106,0.000474943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002133657,"about_ca_system_score_gemma":0.0001491718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002275544,"about_ca_topic_score_gemma":0.0043753,"domain_scores_codex":[0.9998587,0.0000313216,0.00001179351,0.00003984303,0.00003734225,0.00002092929],"domain_scores_gemma":[0.9997039,0.00008084066,0.0001282139,0.00002232139,0.00002935384,0.00003536105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007157141,0.0001218641,0.1873532,0.00006431899,0.0000526103,0.0005818275,0.0002224172,0.0001125785,0.8067611,0.00005541292,0.0001313344,0.003827629],"study_design_scores_gemma":[0.00001659459,0.0003591106,0.9626068,0.000006857727,0.00003429806,0.001072418,0.00009585045,0.0002898115,0.03489611,0.00004739207,0.0005702507,0.000004556936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993754,0.00008362923,0.0002119795,0.00001396765,0.000002670763,0.000002745417,0.0001559003,0.000007898228,0.0001458514],"genre_scores_gemma":[0.9982735,0.0001186325,0.0003364857,0.00002158287,0.000005053744,0.00001114043,0.0005834191,0.000007844012,0.0006423544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002275544,"threshold_uncertainty_score":0.007026255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0429651795959145,"score_gpt":0.2618163179855226,"score_spread":0.2188511383896081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}