{"id":"W2002225487","doi":"10.1023/b:cemn.0000012725.31108.4a","title":"Inhibitory Effects of the Monoamine Oxidase Inhibitor Tranylcypromine on the Cytochrome P450 Enzymes CYP2C19, CYP2C9, and CYP2D6","year":2004,"lang":"en","type":"article","venue":"Cellular and Molecular Neurobiology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Tranylcypromine; Monoamine oxidase inhibitor; Pharmacology; CYP2C9; CYP2C19; Monoamine oxidase; CYP3A4; CYP2D6; Cytochrome P450; Non-competitive inhibition; Dextromethorphan; Enzyme; CYP1A2; Chemistry; Selegiline; Biochemistry; Biology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001520855,0.0004449075,0.0004578813,0.000217249,0.0002511736,0.0002652672,0.0002227194,0.0003060131,0.004651007],"category_scores_gemma":[0.0005932726,0.0002211799,0.0003579638,0.0002254247,0.0002143295,0.0002522168,0.0001548682,0.0005679462,0.0005740216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003067793,"about_ca_system_score_gemma":0.0002928679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002738863,"about_ca_topic_score_gemma":0.006608321,"domain_scores_codex":[0.9998473,0.00004904652,0.00001468442,0.00001877851,0.00002097573,0.00004923163],"domain_scores_gemma":[0.9997544,0.00008004771,0.00005719666,0.00002639427,0.00002531485,0.00005671027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01747275,0.0007967385,0.002444947,0.0003343766,0.0002760822,0.0004221501,0.0001450902,0.000728114,0.9231517,0.0006261287,0.002841902,0.05075978],"study_design_scores_gemma":[0.000723064,0.01351099,0.03915861,0.00002999918,0.000323347,0.00149873,0.000097699,0.002572707,0.9352123,0.0001424355,0.006699559,0.00003063266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860997,0.006620084,0.0005613393,0.0002871355,0.0001537712,0.00003860119,0.0005938593,0.0001057531,0.005539732],"genre_scores_gemma":[0.9917642,0.003955793,0.0003594154,0.00007329958,0.0000729431,0.00001609387,0.000787855,0.00001622386,0.002954107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004651007,"threshold_uncertainty_score":0.0155592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02254054429114349,"score_gpt":0.3001204972931966,"score_spread":0.2775799530020531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}