{"id":"W2002225487","doi":"10.1023/b:cemn.0000012725.31108.4a","title":"Inhibitory Effects of the Monoamine Oxidase Inhibitor Tranylcypromine on the Cytochrome P450 Enzymes CYP2C19, CYP2C9, and CYP2D6","year":2004,"lang":"en","type":"article","venue":"Cellular and Molecular Neurobiology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Tranylcypromine; Monoamine oxidase inhibitor; Pharmacology; CYP2C9; CYP2C19; Monoamine oxidase; CYP3A4; CYP2D6; Cytochrome P450; Non-competitive inhibition; Dextromethorphan; Enzyme; CYP1A2; Chemistry; Selegiline; Biochemistry; Biology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003726399,0.0003741223,0.0004173636,0.00009747806,0.0002820127,0.00001595839,0.0003308614,0.0003192667,0.00002843586],"category_scores_gemma":[0.0001273959,0.0002368404,0.0001713758,0.0001881809,0.0008858407,0.00003199228,0.0002470968,0.0007617601,0.000009627898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001654869,"about_ca_system_score_gemma":0.0000675199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001236643,"about_ca_topic_score_gemma":0.000002677912,"domain_scores_codex":[0.9977387,0.0007998169,0.0003772369,0.0004999425,0.000129175,0.0004551528],"domain_scores_gemma":[0.9987779,0.0004117775,0.0001714731,0.0003824829,0.00005863283,0.0001977291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001422396,0.0002373379,0.00007804154,0.00008255104,0.0001147428,0.00009811074,0.0003119672,0.000133159,0.99163,0.005861963,0.0001637233,0.001146227],"study_design_scores_gemma":[0.002810384,0.0003507766,0.001749823,0.00002963806,0.0002545981,0.00006031331,0.00002061141,0.00007171656,0.9805153,0.0009246915,0.01297405,0.0002381014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872545,0.008305962,0.0001090073,0.002099339,0.0008672075,0.000931007,0.000042126,0.0000311415,0.0003597289],"genre_scores_gemma":[0.9931523,0.001012252,0.00003107377,0.005416315,0.0001851028,0.00006507525,0.00001104029,0.00004043434,0.00008641133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01281032,"threshold_uncertainty_score":0.9658073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02254054429114349,"score_gpt":0.3001204972931966,"score_spread":0.2775799530020531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}