{"id":"W2002287591","doi":"10.1038/nature10751","title":"Structural and functional conservation of key domains in InsP3 and ryanodine receptors","year":2012,"lang":"en","type":"article","venue":"Nature","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":170,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Neurological Disorders and Stroke; Wellcome Trust; National Eye Institute; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Ryanodine receptor; Receptor; Inositol; Transmembrane domain; RYR1; Intracellular; Biochemistry; Inositol trisphosphate receptor; Cell biology; Biophysics; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000200535,0.0002095619,0.0003516063,0.0002191619,0.0002773807,0.0003609164,0.0004758368,0.0004357199,0.00116896],"category_scores_gemma":[0.0002957069,0.0001427345,0.0002754952,0.0001860776,0.000310601,0.0003101459,0.0002976269,0.0005990606,0.0004403134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002960548,"about_ca_system_score_gemma":0.0002538476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007751354,"about_ca_topic_score_gemma":0.0008772363,"domain_scores_codex":[0.9999049,0.00001472675,0.000009539842,0.00001991623,0.00002798209,0.00002293296],"domain_scores_gemma":[0.9997405,0.00005018034,0.00006995358,0.00002739032,0.00003425401,0.00007766252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005588473,0.00004121039,0.0007934566,0.00004866577,0.000009851079,0.0003307994,0.0000461737,0.0003854028,0.993858,0.001069781,0.0001384734,0.002719297],"study_design_scores_gemma":[0.0002069718,0.0008185246,0.09210176,0.00004086117,0.000138573,0.007248887,0.0003251731,0.01131606,0.8737819,0.002174355,0.01177801,0.00006906765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957728,0.0008894755,0.00233568,0.0001017291,0.0000210078,0.000009607751,0.0001766402,0.0000306489,0.0006624662],"genre_scores_gemma":[0.9969158,0.0003099786,0.001499911,0.00007738181,0.00001597237,0.000006736169,0.0003135303,0.00001306918,0.0008477246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00116896,"threshold_uncertainty_score":0.003910601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009180706376252932,"score_gpt":0.233964153883031,"score_spread":0.2247834475067781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}