{"id":"W2002287591","doi":"10.1038/nature10751","title":"Structural and functional conservation of key domains in InsP3 and ryanodine receptors","year":2012,"lang":"en","type":"article","venue":"Nature","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":170,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Neurological Disorders and Stroke; Wellcome Trust; National Eye Institute; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Ryanodine receptor; Receptor; Inositol; Transmembrane domain; RYR1; Intracellular; Biochemistry; Inositol trisphosphate receptor; Cell biology; Biophysics; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007610792,0.0000477178,0.0000477861,0.00003451192,0.00002210581,0.000003269584,0.0000111499,0.0003580077,0.00002030086],"category_scores_gemma":[0.00004495163,0.00004175557,0.00001048729,0.00005106406,0.00003452576,0.000007023647,0.00001671707,0.0001412515,2.680301e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005181883,"about_ca_system_score_gemma":0.00000854435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000409683,"about_ca_topic_score_gemma":0.00001419056,"domain_scores_codex":[0.9997137,0.00001674182,0.00007224309,0.00007951427,0.00005496953,0.00006287265],"domain_scores_gemma":[0.9998536,0.000005856001,0.00003278179,0.00004194396,0.00003899833,0.00002682174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003835767,0.00003146325,0.6185625,0.00004202632,0.00002570908,1.657027e-7,0.0002747064,0.00004468383,0.3652125,0.00433019,0.008052994,0.003039483],"study_design_scores_gemma":[0.0009144351,0.0000707549,0.913189,0.000008840711,0.000005962211,0.0000155521,0.0001081439,0.0002894101,0.04536123,0.0001439567,0.03979179,0.0001009545],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997925,0.001014761,0.0000630455,0.0003125649,0.0004360291,0.00004979326,0.000004987369,0.000002695773,0.0001911313],"genre_scores_gemma":[0.9989464,0.00004842228,0.0001602097,0.0002789195,0.0002244544,0.00000169726,0.0001317822,0.000003688842,0.0002044738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3198512,"threshold_uncertainty_score":0.2761283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009180706376252932,"score_gpt":0.233964153883031,"score_spread":0.2247834475067781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}