{"id":"W2002300978","doi":"10.1016/j.bbrc.2004.04.180","title":"Endosome disruption enhances the functional nuclear delivery of Tat-fusion proteins","year":2004,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Endosome; Internalization; Fusion protein; Endocytosis; Cell biology; Cytosol; Nuclear transport; Lysosome; Lipid bilayer fusion; Chemistry; Biology; Intracellular; Nucleus; Cell nucleus; Biochemistry; Cell; Recombinant DNA; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003116787,0.0004332978,0.0003755422,0.0001982473,0.0002515108,0.0006635639,0.0002690086,0.0004328827,0.001597681],"category_scores_gemma":[0.0002661859,0.0002402351,0.0004065991,0.0001474499,0.0003579287,0.000403404,0.0004875278,0.0008811518,0.0006672696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007563308,"about_ca_system_score_gemma":0.0004122749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001280934,"about_ca_topic_score_gemma":0.001523072,"domain_scores_codex":[0.999724,0.00004369945,0.00003043303,0.00004614419,0.00007091821,0.00008481835],"domain_scores_gemma":[0.9996954,0.00009291217,0.00006888151,0.00003823894,0.00002793246,0.00007665016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007202529,0.00001258329,0.00003690231,0.00001313647,0.00000342859,0.00002643731,0.000009829939,0.00004434778,0.9993299,0.0001679371,0.00001615785,0.0002672318],"study_design_scores_gemma":[0.000006685139,0.00003317716,0.0005661667,0.000001874153,0.000007118167,0.00008944122,0.000007735684,0.0004062692,0.9980575,0.00002455338,0.0007971631,0.000002175262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911723,0.001013691,0.005399877,0.0001983907,0.00003927355,0.00002144304,0.0002838181,0.0001335762,0.001737678],"genre_scores_gemma":[0.9951219,0.000317016,0.001352019,0.00004311004,0.000007310449,0.00001086931,0.0003305426,0.0000573093,0.002759818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001597681,"threshold_uncertainty_score":0.005487621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05670327288263591,"score_gpt":0.3322615719789697,"score_spread":0.2755582990963337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}