{"id":"W2002302430","doi":"10.1182/blood-2005-09-3900","title":"X-inactivation–based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":237,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Myelofibrosis; Essential thrombocythemia; Polycythemia vera; Biology; Allele; Granulopoiesis; Myeloid; Immunology; Genetics; Haematopoiesis; Bone marrow; Gene; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009808795,0.0003794309,0.001077815,0.0003461407,0.0001620148,0.0001018425,0.00004430584,0.0001608087,0.00001487987],"category_scores_gemma":[0.0003141825,0.0003147871,0.0000906658,0.0005302789,0.0002271432,0.0003333701,0.00007346323,0.0002807291,2.933663e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001824992,"about_ca_system_score_gemma":0.0001837088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002966897,"about_ca_topic_score_gemma":0.003370953,"domain_scores_codex":[0.9969814,0.0005215072,0.0007206242,0.0006965727,0.0007772747,0.0003026508],"domain_scores_gemma":[0.9965186,0.001995701,0.000658835,0.0002037508,0.0004754811,0.0001476542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003790438,0.001494007,0.9932839,0.0002475655,0.001984527,0.00001200572,0.0005916219,0.00001060467,0.0003610104,0.001522726,0.00002236356,0.00009056723],"study_design_scores_gemma":[0.009201522,0.0007696631,0.9763524,0.0002256008,0.002684578,0.000002846095,0.0003665791,0.00012382,0.009513843,0.0004877593,0.000004879513,0.0002665074],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960992,0.0001597253,0.0003084268,0.001161386,0.00001134739,0.0009290865,0.001159423,0.00001887814,0.0001525346],"genre_scores_gemma":[0.9933741,0.00006842869,0.005540116,0.0001348309,0.00002316579,0.0001348453,0.0006634073,0.00002161303,0.00003950824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01693155,"threshold_uncertainty_score":0.9999304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0156500770186828,"score_gpt":0.3003505325570687,"score_spread":0.2847004555383859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}