{"id":"W2002302430","doi":"10.1182/blood-2005-09-3900","title":"X-inactivation–based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":237,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Myelofibrosis; Essential thrombocythemia; Polycythemia vera; Biology; Allele; Granulopoiesis; Myeloid; Immunology; Genetics; Haematopoiesis; Bone marrow; Gene; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004413896,0.000186071,0.000130627,0.001145373,0.0001184081,0.0002009773,0.0001586398,0.0002367781,0.00211848],"category_scores_gemma":[0.001119614,0.0000829744,0.00008254863,0.0003086198,0.0002762311,0.0001359114,0.0001685965,0.0001912102,0.0002760887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009943792,"about_ca_system_score_gemma":0.00004133899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002214314,"about_ca_topic_score_gemma":0.0003276246,"domain_scores_codex":[0.9996126,0.0001249829,0.00003613751,0.00007296545,0.00009917813,0.0000542452],"domain_scores_gemma":[0.9993547,0.0003167473,0.0001473885,0.00004875102,0.0000623195,0.00007013188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007632718,0.00008435651,0.7661223,0.00005577246,0.0000672044,0.001170646,0.0002071902,0.0002561421,0.1958434,0.0003171309,0.0003227476,0.03478984],"study_design_scores_gemma":[0.00005011307,0.0005202226,0.9217487,0.00001451112,0.00003894073,0.01603034,0.0001152136,0.002723325,0.05701607,0.0003228578,0.001407173,0.00001246675],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975162,0.000360146,0.001093506,0.00001810525,0.000002543627,0.00000907751,0.00007845723,0.0000215982,0.0009003743],"genre_scores_gemma":[0.9989774,0.00004264637,0.0006956522,0.00001277628,0.000004904273,0.000007117406,0.00008862636,0.00000333251,0.0001675079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00211848,"threshold_uncertainty_score":0.007086992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0156500770186828,"score_gpt":0.3003505325570687,"score_spread":0.2847004555383859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}