{"id":"W2002417408","doi":"10.2174/138920009790820138","title":"Expression, Function and Regulation of Mouse Cytochrome P450 Enzymes: Comparison With Human Cytochrome P450 Enzymes","year":2009,"lang":"en","type":"review","venue":"Current Drug Metabolism","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Cytochrome P450; Aryl hydrocarbon receptor; Constitutive androstane receptor; Biology; Enzyme; Function (biology); Gene; Biochemistry; Receptor; Isozyme; Nuclear receptor; Cell biology; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002169559,0.0004381444,0.0006970203,0.001090124,0.00008480659,0.0004451893,0.0003317758,0.0003039939,0.00168996],"category_scores_gemma":[0.0002359283,0.0001242432,0.0002784506,0.001455862,0.0001436047,0.000466739,0.0001699771,0.0003930716,0.001267266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474248,"about_ca_system_score_gemma":0.0002997721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004448339,"about_ca_topic_score_gemma":0.0005416535,"domain_scores_codex":[0.9998735,0.00001893658,0.00001713063,0.00003101696,0.00004904833,0.00001035605],"domain_scores_gemma":[0.9998856,0.00004046179,0.0000318092,0.000005517267,0.00002772808,0.000008880666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001177449,0.00006783739,0.001122414,0.009211093,0.000103518,0.0005570047,0.00005275392,0.0004912164,0.04615796,0.001753465,0.005949066,0.9344159],"study_design_scores_gemma":[0.00002254895,0.0003443799,0.01171639,0.00107769,0.0003394188,0.007195597,0.00006635573,0.000228326,0.02462735,0.0013262,0.9530264,0.00002924288],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00235119,0.9945273,0.0008345848,0.00008862716,0.00005951348,0.000004995203,0.00006707529,0.00001932336,0.002047402],"genre_scores_gemma":[0.009803006,0.9866647,0.001110991,0.0001000279,0.0001010147,0.00001164194,0.0002115762,0.000004692828,0.001992471],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00168996,"threshold_uncertainty_score":0.005653501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1498512899212153,"score_gpt":0.4583765530236701,"score_spread":0.3085252631024548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}