{"id":"W2002420019","doi":"10.1074/jbc.m111523200","title":"Werner Protein Is a Target of DNA-dependent Protein Kinase in Vivo and in Vitro, and Its Catalytic Activities Are Regulated by Phosphorylation","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Cancer Institute; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Exonuclease; Biology; Genome instability; Helicase; DNA-PKcs; Molecular biology; DNA; Phosphorylation; DNA repair; Werner syndrome; Premature aging; Protein kinase A; Cell biology; DNA damage; Genetics; Gene; DNA polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002298098,0.0001517975,0.0002787589,0.0000309921,0.00001584055,0.00001102498,0.0001040489,0.0002980638,0.0000611202],"category_scores_gemma":[0.0001501635,0.0001210228,0.00005207803,0.00006863784,0.00007141206,0.00001067719,0.0000770238,0.0001852824,2.123189e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003230055,"about_ca_system_score_gemma":0.00001708661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004531598,"about_ca_topic_score_gemma":0.000001028817,"domain_scores_codex":[0.9990435,0.00004574974,0.0003788069,0.000232225,0.0001310938,0.0001686587],"domain_scores_gemma":[0.9994127,0.000009837993,0.0003417289,0.0001071431,0.00005131414,0.00007729033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003598917,0.0001591245,0.0006701507,0.0000751725,0.00001826201,0.00002695623,0.00002903274,0.00000269729,0.9984123,6.331855e-7,0.00005289864,0.0001929317],"study_design_scores_gemma":[0.0008538896,0.0001883552,0.000284689,0.0001002452,0.000005103286,0.00005265992,0.00009064074,0.0001609913,0.9978909,0.00008270652,0.0001542851,0.0001354703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967122,0.002859674,0.000009568519,0.000115372,0.000008880191,0.0001909269,0.00004038977,0.00000314156,0.00005985476],"genre_scores_gemma":[0.9990985,0.0001396786,0.0001960949,0.00002533585,0.00002985692,0.00001315824,0.000008001716,0.000008876505,0.000480481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002719995,"threshold_uncertainty_score":0.4935165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01003320720309983,"score_gpt":0.2084469525599649,"score_spread":0.1984137453568651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}