{"id":"W2002424665","doi":"10.1038/ng1958","title":"Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity","year":2007,"lang":"en","type":"article","venue":"Nature Genetics","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":362,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity; University of Calgary","funders":"Wellcome Trust","keywords":"Biology; Immune system; Autoimmunity; Regulatory T cell; IL-2 receptor; Allele; T cell; Gene; Autoimmune disease; Immunology; Genetics; Cytokine; Homeostasis; Interleukin 2; Cell biology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000237534,0.0009189397,0.0003830523,0.0008254247,0.0002468346,0.0004181957,0.0004800459,0.000790928,0.003800212],"category_scores_gemma":[0.0004043572,0.0003784398,0.0003461579,0.0004383994,0.0006619712,0.0001561309,0.0003738211,0.001331303,0.0003990254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002687207,"about_ca_system_score_gemma":0.0002512098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000451173,"about_ca_topic_score_gemma":0.0007252884,"domain_scores_codex":[0.999459,0.0001801656,0.00005440092,0.0001135639,0.0001034163,0.00008942726],"domain_scores_gemma":[0.999326,0.0002471014,0.0001832886,0.0000709403,0.00001846467,0.000154205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004825646,0.00009765769,0.0006623558,0.00001877118,0.00002456427,0.0004064572,0.00001810204,0.0001575302,0.9968904,0.0002150603,0.00008396034,0.0009425531],"study_design_scores_gemma":[0.0008310642,0.001291792,0.04301022,0.00002357316,0.0003457694,0.007479593,0.0001330483,0.004330467,0.9376835,0.0009354998,0.003865399,0.00007011974],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967038,0.0001802035,0.001507288,0.0001467807,0.0000582846,0.0000123945,0.0002752123,0.000180271,0.0009357067],"genre_scores_gemma":[0.9973974,0.000175775,0.0009990283,0.00008508051,0.00003584591,0.0000168365,0.0001762642,0.0001334838,0.0009803083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003800212,"threshold_uncertainty_score":0.01271296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006191305024200562,"score_gpt":0.2143111694820324,"score_spread":0.2081198644578318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}