{"id":"W2002455191","doi":"10.1016/j.bbadis.2012.12.008","title":"Involvement of kinase PKC-zeta in the p62/p62P392L-driven activation of NF-κB in human osteoclasts","year":2012,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"NF-κB; Protein kinase C; Cell biology; Chemistry; Kinase; NFKB1; Signal transduction; Biology; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002842018,0.000310695,0.0004112259,0.0002033863,0.00003560861,0.00001351969,0.0005229799,0.0001251438,0.000009853961],"category_scores_gemma":[0.0001578411,0.0002669733,0.0003399517,0.0003948866,0.0002502443,0.00003264831,0.0002339206,0.000115339,0.000001246245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001709941,"about_ca_system_score_gemma":0.000160395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000127035,"about_ca_topic_score_gemma":0.00001579755,"domain_scores_codex":[0.9977828,0.000382371,0.0006196956,0.0004080037,0.000440167,0.0003669219],"domain_scores_gemma":[0.9983274,0.00003568711,0.000423826,0.0009112157,0.0001120783,0.0001897598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004465325,0.002267292,0.002577813,0.0002294345,0.00007694326,0.000002408188,0.0002508942,0.00003839555,0.9931266,0.0006722442,0.0001437529,0.0001676468],"study_design_scores_gemma":[0.001093321,0.0001681522,0.1293831,0.0001078354,0.00013172,2.044532e-7,0.0001909132,0.00001266825,0.868502,0.0001146271,0.00006436715,0.0002310243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979389,0.0006718261,0.00003600088,0.0003774531,0.00004574167,0.0005357604,0.0002418216,0.000006298851,0.0001461658],"genre_scores_gemma":[0.9986813,0.0001124206,0.000161934,0.0003305737,0.00007241134,0.00006848444,0.0005310169,0.00003504883,0.000006800768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1268053,"threshold_uncertainty_score":0.9999782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272858672241132,"score_gpt":0.2624385282968186,"score_spread":0.2497099415744073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}