{"id":"W2002522727","doi":"10.1074/jbc.m109.091124","title":"3BP2 Adapter Protein Is Required for Receptor Activator of NFκB Ligand (RANKL)-induced Osteoclast Differentiation of RAW264.7 Cells","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Agence Nationale de la Recherche","keywords":"RANKL; Osteoclast; Activator (genetics); Adapter (computing); Cell biology; RANK Ligand; NF-κB; Chemistry; Signal transducing adaptor protein; Receptor; Ligand (biochemistry); Cancer research; Signal transduction; Biology; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001871907,0.0005757943,0.0004017077,0.0002881814,0.0003145558,0.0003943566,0.0002069279,0.0003801651,0.002472089],"category_scores_gemma":[0.0001412518,0.0002803414,0.0005154047,0.0002730612,0.0002229797,0.0001848954,0.000360741,0.0006656376,0.001377582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004344147,"about_ca_system_score_gemma":0.0004435134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001755879,"about_ca_topic_score_gemma":0.002472006,"domain_scores_codex":[0.9996042,0.00004538559,0.00003611718,0.00006560422,0.000154884,0.00009383589],"domain_scores_gemma":[0.9998223,0.00001535574,0.0000498806,0.0000231612,0.00002645135,0.00006285104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005184627,0.000009052422,0.00007552809,0.00002251149,0.000003238872,0.00005343897,0.000006806188,0.000009976276,0.9994967,0.00003693108,0.00004191226,0.0001920568],"study_design_scores_gemma":[0.00006110247,0.0001813477,0.0176275,0.00001544325,0.00003065986,0.00105847,0.00006092959,0.001423983,0.9699128,0.00009549511,0.009519933,0.00001247236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980848,0.003111169,0.008356669,0.0003303713,0.0001292747,0.00006344907,0.003791103,0.0003475643,0.003022351],"genre_scores_gemma":[0.9801603,0.000991705,0.003435171,0.0001670966,0.00002302634,0.0001257833,0.007330297,0.0000846652,0.007681888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002472089,"threshold_uncertainty_score":0.008270025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01778159893163717,"score_gpt":0.2451608756369935,"score_spread":0.2273792767053563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}