{"id":"W2002546148","doi":"10.1002/cmdc.201000120","title":"Heme Oxygenase Inhibition by 1‐Aryl‐2‐(1<i>H</i>‐imidazol‐1‐yl/1<i>H</i>‐1,2,4‐triazol‐1‐yl)ethanones and Their Derivatives","year":2010,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Moiety; Imidazole; Azole; Aryl; Stereochemistry; Triazole; Heme oxygenase; Selectivity; Heme; Regioselectivity; Medicinal chemistry; Enzyme; Organic chemistry; Catalysis; Alkyl","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001180673,0.000265939,0.0002050167,0.00009759741,0.0001088781,0.0001270528,0.0001911481,0.0001233992,0.0006937023],"category_scores_gemma":[0.00007411623,0.00009251654,0.0001362187,0.0001159698,0.0001301479,0.0001204947,0.0001046047,0.0003565447,0.0002244324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002263038,"about_ca_system_score_gemma":0.0002163767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005984532,"about_ca_topic_score_gemma":0.002159674,"domain_scores_codex":[0.9999232,0.00001418252,0.000007588757,0.00001281303,0.00001324245,0.000028955],"domain_scores_gemma":[0.9999485,0.000007517787,0.00001799261,0.000004552199,0.000007234827,0.00001415732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002448163,0.0001302395,0.0001951544,0.00007478461,0.000005862445,0.00008547123,0.00002140626,0.0003050669,0.9947144,0.00007550525,0.00007776472,0.004069495],"study_design_scores_gemma":[0.000125083,0.003017071,0.004254781,0.000008783578,0.0000272671,0.0003031586,0.00003168069,0.001184825,0.9884827,0.00002632254,0.00252726,0.00001120855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936529,0.003378282,0.001285044,0.0000631686,0.00002263159,0.0000330131,0.0001368105,0.00004703927,0.001381021],"genre_scores_gemma":[0.9919591,0.003011593,0.002546396,0.00005903159,0.00001152024,0.00004804913,0.0002412177,0.000007361583,0.002115743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006937023,"threshold_uncertainty_score":0.002320707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005611641886590336,"score_gpt":0.2099209081701811,"score_spread":0.2043092662835907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}