{"id":"W2002546148","doi":"10.1002/cmdc.201000120","title":"Heme Oxygenase Inhibition by 1‐Aryl‐2‐(1<i>H</i>‐imidazol‐1‐yl/1<i>H</i>‐1,2,4‐triazol‐1‐yl)ethanones and Their Derivatives","year":2010,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Moiety; Imidazole; Azole; Aryl; Stereochemistry; Triazole; Heme oxygenase; Selectivity; Heme; Regioselectivity; Medicinal chemistry; Enzyme; Organic chemistry; Catalysis; Alkyl","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003794668,0.0005386919,0.0003900327,0.00007252113,0.0001943953,0.00009173398,0.0002908183,0.0005207791,0.0001024348],"category_scores_gemma":[0.0002342114,0.0004835649,0.0001826806,0.0002051008,0.0003785771,0.00002633995,0.0002638864,0.0004390581,0.00002867218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001783711,"about_ca_system_score_gemma":0.0001094391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000238746,"about_ca_topic_score_gemma":0.00005856557,"domain_scores_codex":[0.9977632,0.0000471733,0.0004363077,0.0008945929,0.0002162304,0.0006425166],"domain_scores_gemma":[0.9985146,0.00005462953,0.0001786806,0.0007137787,0.0001329026,0.0004053992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008494486,0.0001221731,0.0008312896,0.00004272782,0.00006988535,0.000006621647,0.0001984776,3.773894e-7,0.9823297,0.000137193,0.01367291,0.002503728],"study_design_scores_gemma":[0.001116272,0.0001093874,0.0005745465,0.00002007069,0.00001942467,0.00005260584,0.0003216967,0.0000256274,0.9410309,0.0003778929,0.05576601,0.0005855464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933425,0.001484677,0.0004211897,0.0008561907,0.0002759153,0.000330672,0.0001141635,0.00008664814,0.003088037],"genre_scores_gemma":[0.9951844,0.0004407956,0.0006494441,0.001358855,0.0006554854,0.0001101536,0.0006790044,0.00009219324,0.0008296205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04209309,"threshold_uncertainty_score":0.9997616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005611641886590336,"score_gpt":0.2099209081701811,"score_spread":0.2043092662835907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}