{"id":"W2002555240","doi":"10.1186/1472-6807-11-36","title":"Novel dimeric β-helical model of an ice nucleation protein with bridged active sites","year":2011,"lang":"en","type":"article","venue":"BMC Structural Biology","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Queen's University; Canada Research Chairs","keywords":"Antifreeze protein; Nucleation; Ice nucleus; Chemistry; Crystallography; Ice crystals; Biophysics; Protein structure; Polar; Amino acid; Ice formation; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002009457,0.00009808812,0.0001227812,0.000009719956,0.00004997377,0.00000203692,0.0001532425,0.00007495985,0.0003713823],"category_scores_gemma":[0.00002667602,0.00005678544,0.00002860941,0.0001012819,0.0003855441,0.0001040629,0.00007554029,0.0000729369,0.00001818342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002119487,"about_ca_system_score_gemma":0.000006386624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003430629,"about_ca_topic_score_gemma":0.00007360373,"domain_scores_codex":[0.9993967,0.00003047912,0.000118255,0.0002447246,0.00006048522,0.0001493711],"domain_scores_gemma":[0.9997202,0.0000196809,0.00007746192,0.0001098132,0.00001203053,0.00006086084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001974061,0.00003867568,0.002635275,0.000002016417,0.000004471467,6.838765e-8,0.00009206567,0.0002125091,0.9946057,0.0006327423,0.000001800269,0.00157726],"study_design_scores_gemma":[0.0002743469,0.0006215202,0.4454766,0.000002563499,0.000009664351,0.000004030133,0.00003807028,0.01915405,0.5256051,0.008656356,0.000004106682,0.0001536146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974416,0.000001682739,0.001742189,0.00001228337,0.00000892118,0.0001633216,0.00003266569,0.00002358948,0.000573715],"genre_scores_gemma":[0.9604586,2.712371e-7,0.03938084,0.00005329066,0.00001273507,0.00001299359,0.00004819622,0.000003816593,0.00002924518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4690006,"threshold_uncertainty_score":0.4066375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05187523365510365,"score_gpt":0.2416010180782378,"score_spread":0.1897257844231341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}