{"id":"W2002567921","doi":"10.1074/jbc.m411151200","title":"Bioluminescence Resonance Energy Transfer Reveals Ligand-induced Conformational Changes in CXCR4 Homo- and Heterodimers","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":256,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"","keywords":"Ligand (biochemistry); Dimer; Receptor; Chemistry; Biophysics; Förster resonance energy transfer; G protein-coupled receptor; Chemokine receptor; Bioluminescence; Conformational change; Transmembrane protein; Resonance (particle physics); Stereochemistry; Chemokine; Biochemistry; Biology; Fluorescence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000253732,0.0001151925,0.0003301843,0.00003479228,0.00002387199,0.00001064812,0.00006967231,0.0001732143,0.0001152837],"category_scores_gemma":[0.00009884854,0.00007662317,0.00007491413,0.00009370303,0.00006439137,0.00005299789,0.00001471512,0.0002394557,6.349254e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004863779,"about_ca_system_score_gemma":0.00003611135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002633288,"about_ca_topic_score_gemma":0.000001639514,"domain_scores_codex":[0.9991683,0.00001412003,0.0003881706,0.0001163329,0.0001491645,0.0001638868],"domain_scores_gemma":[0.9995639,0.0000656212,0.00009556265,0.00005933934,0.00008660796,0.0001289219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001734664,0.00006647441,0.008643712,0.00003644613,0.00001189396,0.00002002178,0.00005811453,9.000875e-7,0.9812422,0.000006467035,0.0001089994,0.009631271],"study_design_scores_gemma":[0.001210124,0.0001872781,0.008823071,0.0002625856,0.00001186347,0.0005342835,0.00007031403,0.00005929274,0.9822317,0.0000170259,0.006483472,0.000108943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995859,0.001918194,0.0000312357,0.001819079,0.00002647949,0.00003102223,0.00000379721,0.000006178094,0.0003050233],"genre_scores_gemma":[0.9973933,0.001305613,0.0002514643,0.0004859147,0.0004680264,0.000001853851,0.000005693791,0.000004460859,0.0000836696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009522327,"threshold_uncertainty_score":0.3124602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02657755756335274,"score_gpt":0.2575197734408224,"score_spread":0.2309422158774697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}