{"id":"W2002589386","doi":"10.1038/mt.2011.39","title":"Sequential Therapy With JX-594, A Targeted Oncolytic Poxvirus, Followed by Sorafenib in Hepatocellular Carcinoma: Preclinical and Clinical Demonstration of Combination Efficacy","year":2011,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Dong-A University; Korea Food and Drug Administration; Pfizer","keywords":"Sorafenib; Oncolytic virus; Hepatocellular carcinoma; Medicine; Virology; Combination therapy; Cancer research; Oncology; Internal medicine; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009610897,0.0003013683,0.0004185588,0.0001132157,0.0000613648,0.00002433795,0.0003067282,0.0003635176,0.00004116889],"category_scores_gemma":[0.00004438284,0.0002678407,0.0001812067,0.000246651,0.0003537003,0.00001364802,0.00005065531,0.0002800233,0.000003411519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000263085,"about_ca_system_score_gemma":0.0002697266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001212874,"about_ca_topic_score_gemma":0.00008913545,"domain_scores_codex":[0.9971833,0.0007682329,0.0006580278,0.0006583434,0.0003603868,0.0003717142],"domain_scores_gemma":[0.9988611,0.0000466698,0.0002260291,0.0005553034,0.0001597724,0.0001511597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01383025,0.001519107,0.1163679,0.000008178169,0.0002271511,0.00003549644,0.0001395575,0.000004737211,0.8594469,0.00003454782,0.00005136635,0.008334792],"study_design_scores_gemma":[0.01328638,0.0138981,0.02507605,0.00001773537,0.00002193884,0.000008670317,0.00002792311,0.0003706473,0.9465642,0.00009863435,0.000296459,0.0003332687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927905,0.004433672,0.001324234,0.00009380643,0.00005974972,0.001137435,0.00001481102,0.00001833612,0.0001274284],"genre_scores_gemma":[0.99729,0.001609028,0.000480655,0.0002312201,0.0000377306,0.00006460876,0.0001772013,0.0000658831,0.00004374164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09129183,"threshold_uncertainty_score":0.9999774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05034979870484539,"score_gpt":0.3294134681094897,"score_spread":0.2790636694046443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}