{"id":"W2002589386","doi":"10.1038/mt.2011.39","title":"Sequential Therapy With JX-594, A Targeted Oncolytic Poxvirus, Followed by Sorafenib in Hepatocellular Carcinoma: Preclinical and Clinical Demonstration of Combination Efficacy","year":2011,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Dong-A University; Korea Food and Drug Administration; Pfizer","keywords":"Sorafenib; Oncolytic virus; Hepatocellular carcinoma; Medicine; Virology; Combination therapy; Cancer research; Oncology; Internal medicine; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000555937,0.0004681959,0.001018205,0.0003921227,0.0002144466,0.0003714091,0.0004291935,0.0003139937,0.0009140543],"category_scores_gemma":[0.0003176293,0.000238959,0.0004760673,0.0002754408,0.0004125941,0.0003801776,0.0002823642,0.0008817611,0.0001755381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004053595,"about_ca_system_score_gemma":0.0004436249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000721294,"about_ca_topic_score_gemma":0.00157536,"domain_scores_codex":[0.999769,0.00006781866,0.00002589292,0.00003758333,0.00004688674,0.00005285164],"domain_scores_gemma":[0.9998012,0.00004704026,0.00003791011,0.00003024747,0.0000143682,0.00006915203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.04763726,0.01718526,0.004826051,0.000628467,0.0004112066,0.0006420795,0.0002990864,0.003805102,0.7781748,0.0004143036,0.0005336124,0.1454428],"study_design_scores_gemma":[0.01845507,0.4954568,0.03388601,0.00004107402,0.0007884746,0.002854291,0.0001653579,0.009487046,0.4330913,0.0002212657,0.005492251,0.00006105862],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973623,0.001103154,0.0006838338,0.00004618848,0.0000285833,0.0001123818,0.00005280981,0.00003308379,0.0005777067],"genre_scores_gemma":[0.9981945,0.0006417626,0.0006264333,0.00001964145,0.00002258945,0.00006206837,0.0001113549,0.000005400939,0.0003162709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001018205,"threshold_uncertainty_score":0.003057837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05034979870484539,"score_gpt":0.3294134681094897,"score_spread":0.2790636694046443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}