{"id":"W2002610788","doi":"10.1016/s0301-4622(02)00300-9","title":"Lipid binding ability of human apolipoprotein E N-terminal domain isoforms: correlation with protein stability?","year":2002,"lang":"en","type":"article","venue":"Biophysical Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Chemistry; Circular dichroism; Gene isoform; Vesicle; Denaturation (fissile materials); Guanidine; Apolipoprotein B; Lipid bilayer; Apolipoprotein E; Biophysics; Bilayer; Helix (gastropod); Biochemistry; Crystallography; Cholesterol; Membrane; Biology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008095696,0.0001976844,0.0003190601,0.00002418476,0.0001015492,0.00001295309,0.00008855911,0.0001026717,0.0006874035],"category_scores_gemma":[0.00003922647,0.0001457215,0.0001305526,0.0002039533,0.0003629412,0.00009814426,0.00004261839,0.0002290054,0.00004771757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001538077,"about_ca_system_score_gemma":0.00006656558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003204512,"about_ca_topic_score_gemma":9.940914e-7,"domain_scores_codex":[0.9985169,0.00002558656,0.0002593348,0.0003601717,0.0005054364,0.0003326071],"domain_scores_gemma":[0.9989945,0.00002487047,0.0001116153,0.0004494299,0.0001043423,0.0003152791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003404368,0.002236166,0.01218558,0.0007418127,0.0005162577,0.00006242949,0.00008855292,1.970965e-7,0.9832731,0.00003288973,0.00002410013,0.000498505],"study_design_scores_gemma":[0.002415596,0.0007127141,0.007830678,0.0002833371,0.0001639007,0.00002544127,0.0001343774,0.0001688748,0.9878482,0.0001975444,0.00001775004,0.0002016165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973401,0.00005771121,0.00001676377,0.0001045563,0.000004581479,0.0006875792,0.00004683321,0.00005046001,0.001691446],"genre_scores_gemma":[0.9991718,0.000001195079,0.0003333972,0.000004347125,0.0001610295,0.0001118729,0.00008779449,0.00002007803,0.0001085141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004575099,"threshold_uncertainty_score":0.7526586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02484307020218855,"score_gpt":0.2747077815298671,"score_spread":0.2498647113276786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}