{"id":"W2002633641","doi":"10.1016/j.mcn.2011.03.004","title":"Patched1 haploinsufficiency impairs ependymal cilia function of the quaking viable mice, leading to fatal hydrocephalus","year":2011,"lang":"en","type":"article","venue":"Molecular and Cellular Neuroscience","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Multiple Sclerosis Society; Multiple Sclerosis Society of Canada","keywords":"Biology; Haploinsufficiency; Cilium; Ependymal Cell; Ependyma; Hydrocephalus; Function (biology); Motile cilium; Cell biology; Neuroscience; Anatomy; Genetics; Phenotype; Central nervous system; Gene; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002741266,0.0001879036,0.0001588471,0.0000585331,0.0002522583,0.00002476381,0.000387489,0.00007208902,0.000004319139],"category_scores_gemma":[0.0001607733,0.0001535128,0.0001050824,0.0003440428,0.0002448827,0.00001000538,0.0003817652,0.0001036049,0.00000420159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008469036,"about_ca_system_score_gemma":0.00005752206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004404105,"about_ca_topic_score_gemma":0.00001031522,"domain_scores_codex":[0.9985115,0.00007689098,0.0002303453,0.0005567982,0.0002684658,0.0003559923],"domain_scores_gemma":[0.9993436,0.00000594745,0.00009788242,0.0003793877,0.00006667029,0.0001065072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002544483,0.00005669502,0.001594889,0.00001780214,0.000005341674,0.00001209153,0.0003023982,0.0001945175,0.9971601,0.0001061584,0.00001878191,0.0005057435],"study_design_scores_gemma":[0.0001506183,0.0004496315,0.002626574,0.00001849371,0.00002271774,0.00001609545,0.0001343942,0.0002269973,0.9954104,0.00005335672,0.0007088869,0.0001818286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9640471,0.0004377513,0.0338274,0.0000257074,0.0003129122,0.0002055295,0.000006797165,0.00001461485,0.00112213],"genre_scores_gemma":[0.9991214,0.000009142768,0.0002350811,0.0004263592,0.00002543123,0.00001081888,0.000002070592,0.00001991856,0.0001497812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03507424,"threshold_uncertainty_score":0.626007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01859592598160866,"score_gpt":0.2185354742623738,"score_spread":0.1999395482807652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}