{"id":"W2002706738","doi":"10.1371/journal.pone.0024693","title":"Discovery of Dual-Action Membrane-Anchored Modulators of Incretin Receptors","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Drug Abuse; Harvard Digestive Diseases Center, Harvard University; National Institutes of Health; Canadian Institutes of Health Research; Université Laval","keywords":"Receptor; G protein-coupled receptor; Incretin; Endocytosis; Cell biology; Glucagon-like peptide 1 receptor; Biochemistry; Gastric inhibitory polypeptide; Peptide; Chemistry; Biology; Endocrinology; Agonist; Glucagon; Hormone; Type 2 diabetes","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002339285,0.0003513879,0.0002795993,0.0001419118,0.00007190269,0.0003505626,0.0003369467,0.0003840711,0.001203478],"category_scores_gemma":[0.0001677388,0.0001247832,0.0002400711,0.00009866116,0.0001794612,0.0002606629,0.0003920431,0.0005980437,0.0004375323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002708851,"about_ca_system_score_gemma":0.0001318442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005877083,"about_ca_topic_score_gemma":0.00008753112,"domain_scores_codex":[0.9998997,0.00001956916,0.000008277572,0.00001927444,0.00002715748,0.00002602947],"domain_scores_gemma":[0.9999329,0.00001006348,0.00002365924,0.000005863287,0.00001022566,0.00001733215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008360911,0.00003375121,0.0001112704,0.00005569604,0.0000076875,0.00008844477,0.0000120152,0.0001822822,0.9958739,0.0004135013,0.00006745601,0.003070356],"study_design_scores_gemma":[0.00006339703,0.0006307389,0.0004963877,0.00000919797,0.00002379412,0.0002832366,0.00001263877,0.001207026,0.9898235,0.00006624959,0.007376417,0.000007334821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777133,0.002819438,0.01574846,0.0003487429,0.00007618141,0.0001436819,0.0002792623,0.0001549637,0.002715948],"genre_scores_gemma":[0.968787,0.003257239,0.02406097,0.0002209494,0.00004932888,0.0001747234,0.000393332,0.00003404019,0.003022415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001203478,"threshold_uncertainty_score":0.004026055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06971485902262334,"score_gpt":0.237296387344607,"score_spread":0.1675815283219836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}