{"id":"W2002712538","doi":"10.4161/sgtp.19422","title":"Rags connect mTOR and autophagy","year":2012,"lang":"en","type":"article","venue":"Small GTPases","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Cancer Research UK","keywords":"Autophagy; PI3K/AKT/mTOR pathway; Cell biology; Biology; RPTOR; Lysosome; Catabolism; Regulator; mTORC1; Mechanistic target of rapamycin; Compartment (ship); Anabolism; Amino acid; mTORC2; ULK1; Signal transduction; Biochemistry; Kinase; Protein kinase A; Metabolism; Apoptosis; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004455489,0.0003704263,0.0003086875,0.0006959166,0.0004642053,0.001709076,0.0003310665,0.0006504253,0.003250726],"category_scores_gemma":[0.0005136636,0.0002506567,0.0002677239,0.000312806,0.001017176,0.001280487,0.001473406,0.001128376,0.001179424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005707621,"about_ca_system_score_gemma":0.0004704068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003423948,"about_ca_topic_score_gemma":0.0004882709,"domain_scores_codex":[0.9996374,0.0001048026,0.00001911002,0.00007284836,0.00007759254,0.00008827962],"domain_scores_gemma":[0.9997762,0.00005242542,0.00004981882,0.00002524548,0.00003962501,0.00005674538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001796088,0.0001795051,0.008056337,0.001846769,0.0003789079,0.004965335,0.001678343,0.003445659,0.354842,0.2510992,0.03496743,0.3367444],"study_design_scores_gemma":[0.0001588169,0.0005159914,0.02154532,0.000570699,0.0003575504,0.00770317,0.001334485,0.00367873,0.1697284,0.1824538,0.6117895,0.000163506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.449408,0.3306073,0.03406854,0.03849497,0.003050152,0.0001082464,0.000833124,0.001527422,0.1419022],"genre_scores_gemma":[0.9273608,0.04223951,0.00635589,0.002688422,0.0009961402,0.00004445584,0.0002333239,0.0000798295,0.02000163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003250726,"threshold_uncertainty_score":0.01087475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02750404384410852,"score_gpt":0.2752232845304723,"score_spread":0.2477192406863638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}