{"id":"W2002712538","doi":"10.4161/sgtp.19422","title":"Rags connect mTOR and autophagy","year":2012,"lang":"en","type":"article","venue":"Small GTPases","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Cancer Research UK","keywords":"Autophagy; PI3K/AKT/mTOR pathway; Cell biology; Biology; RPTOR; Lysosome; Catabolism; Regulator; mTORC1; Mechanistic target of rapamycin; Compartment (ship); Anabolism; Amino acid; mTORC2; ULK1; Signal transduction; Biochemistry; Kinase; Protein kinase A; Metabolism; Apoptosis; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009082857,0.0001150147,0.0001835596,0.00004735065,0.00005549431,0.00001015464,0.00003753044,0.00005681456,0.0007446681],"category_scores_gemma":[0.00006681653,0.00009154037,0.00005871973,0.00005997521,0.00006231599,0.00007056313,0.00002402362,0.00007267592,0.0001183618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001525137,"about_ca_system_score_gemma":0.0000360221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001929759,"about_ca_topic_score_gemma":0.000001335145,"domain_scores_codex":[0.9993793,0.00002358469,0.0001129328,0.0001300045,0.00009105395,0.0002631736],"domain_scores_gemma":[0.9994127,0.00007608733,0.00003166886,0.000189477,0.00002522752,0.0002648622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002298652,0.003759589,0.6546381,0.000983263,0.001476032,0.0008109981,0.005232904,0.000002214812,0.1209058,0.04776019,0.02872643,0.1334058],"study_design_scores_gemma":[0.004467266,0.0005008052,0.7464004,0.0001320828,0.0003717752,0.0003195185,0.0003620363,0.00007408699,0.1551984,0.0005526916,0.09115969,0.0004612533],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866368,0.00920606,0.00007984376,0.0003004929,0.0002160328,0.0001760754,0.000009140654,0.0001130342,0.003262572],"genre_scores_gemma":[0.9952624,0.0001271227,0.0002749077,0.001781768,0.0004646371,0.00001877548,0.00001434682,0.00001974686,0.002036311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1329445,"threshold_uncertainty_score":0.8153593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02750404384410852,"score_gpt":0.2752232845304723,"score_spread":0.2477192406863638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}