{"id":"W2002727024","doi":"10.1016/j.bbrc.2003.11.140","title":"Potential for germ line transmission after intramyocardial gene delivery by adeno-associated virus","year":2003,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Transgene; Adeno-associated virus; Genetic enhancement; Gene delivery; Gene expression; Biology; Gene; Ventricle; Ectopic expression; Viral vector; Germ cell; Genetically modified mouse; Seminiferous tubule; Sertoli cell; Molecular biology; Andrology; Vector (molecular biology); Internal medicine; Medicine; Endocrinology; Spermatogenesis; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000709392,0.0001908116,0.0002021713,0.00006571541,0.0003930166,0.0000721611,0.0006237619,0.0003015159,0.00002694005],"category_scores_gemma":[0.0004253059,0.0001716534,0.0001605809,0.0003276982,0.0007643582,0.000008131536,0.0002657236,0.0004387821,0.00001247124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004945801,"about_ca_system_score_gemma":0.0002147914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003385486,"about_ca_topic_score_gemma":0.00001521214,"domain_scores_codex":[0.9977379,0.0005167102,0.0002502251,0.0004804701,0.0004233647,0.0005912689],"domain_scores_gemma":[0.9980491,0.0001678962,0.00003676844,0.0008804243,0.0005231923,0.0003426294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001572988,0.0006488102,0.000009957766,0.00001428399,0.00008473937,8.544816e-7,0.00001879537,7.150302e-7,0.9875109,0.00005995192,0.005073215,0.005004806],"study_design_scores_gemma":[0.0009862547,0.001565794,0.00008799835,0.00001458509,0.00002212748,0.00000249308,0.0000181481,0.0003431118,0.9695891,0.000421616,0.02672656,0.0002222417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897374,0.007097898,0.0006938383,0.001395472,0.00002216667,0.0005705112,0.0003515007,0.00001947526,0.0001117709],"genre_scores_gemma":[0.9913488,0.005652888,0.001091515,0.0001677597,0.0001473297,0.0003482984,0.0008970973,0.00003579298,0.000310509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02165335,"threshold_uncertainty_score":0.6999822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03036600768478977,"score_gpt":0.3421084020987938,"score_spread":0.311742394414004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}