{"id":"W2002727024","doi":"10.1016/j.bbrc.2003.11.140","title":"Potential for germ line transmission after intramyocardial gene delivery by adeno-associated virus","year":2003,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Transgene; Adeno-associated virus; Genetic enhancement; Gene delivery; Gene expression; Biology; Gene; Ventricle; Ectopic expression; Viral vector; Germ cell; Genetically modified mouse; Seminiferous tubule; Sertoli cell; Molecular biology; Andrology; Vector (molecular biology); Internal medicine; Medicine; Endocrinology; Spermatogenesis; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009024888,0.0003403709,0.0002287085,0.0003696788,0.0003542463,0.0006274296,0.0006062831,0.0007244263,0.00212776],"category_scores_gemma":[0.001182955,0.0002418193,0.0003292861,0.00007641962,0.0003795546,0.0008216509,0.0004785793,0.0007797679,0.0007543784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002247217,"about_ca_system_score_gemma":0.000201865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003800363,"about_ca_topic_score_gemma":0.0002887972,"domain_scores_codex":[0.9997097,0.0001232392,0.00001768571,0.00004189245,0.00005354678,0.00005398056],"domain_scores_gemma":[0.9987741,0.0007289028,0.0001210958,0.0001857945,0.00008278216,0.0001073814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003023495,0.00003650091,0.0006104482,0.00006680556,0.00001220196,0.0003178422,0.0000870177,0.00007980892,0.9934144,0.002043045,0.00009059444,0.002938914],"study_design_scores_gemma":[0.0000823951,0.001523932,0.005110333,0.00004045776,0.00009293362,0.002905782,0.0001391359,0.001869381,0.9826182,0.0008884065,0.004713205,0.00001598509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728507,0.003659351,0.01802825,0.0002081905,0.00007494099,0.00007652547,0.0001575449,0.0002063006,0.004738221],"genre_scores_gemma":[0.9937112,0.0007749243,0.00284189,0.00003849945,0.00001721063,0.00003491102,0.0001807317,0.00005423952,0.002346453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00212776,"threshold_uncertainty_score":0.007118106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03036600768478977,"score_gpt":0.3421084020987938,"score_spread":0.311742394414004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}