{"id":"W2002734029","doi":"10.1038/nsmb.1978","title":"Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme","year":2011,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Allosteric regulation; Isothermal titration calorimetry; Allosteric enzyme; Biophysics; Chemistry; Circular dichroism; Folding (DSP implementation); Cooperative binding; Substrate (aquarium); Protein folding; Crystallography; Binding site; Enzyme; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008407127,0.0002932459,0.0006527664,0.0002804761,0.0006153499,0.001809578,0.0009693501,0.00090685,0.003029404],"category_scores_gemma":[0.001370081,0.0005920985,0.0003201902,0.0002391228,0.0007013144,0.001177622,0.0008835613,0.001515767,0.0008307533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005058111,"about_ca_system_score_gemma":0.0002425233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002281016,"about_ca_topic_score_gemma":0.0006422899,"domain_scores_codex":[0.9994913,0.0001054259,0.00004074984,0.0001113398,0.0001435769,0.0001075499],"domain_scores_gemma":[0.9991661,0.0003659575,0.00008418524,0.0001184511,0.00007733277,0.0001879454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006833069,0.0002468182,0.001443052,0.0001127073,0.0000321886,0.0002686625,0.0001545163,0.0009487279,0.9822614,0.006757846,0.000482014,0.006608579],"study_design_scores_gemma":[0.0002179945,0.0004834758,0.004686024,0.0000249875,0.00008291088,0.0009065803,0.0003118573,0.07759273,0.9069199,0.005722586,0.002949705,0.0001012914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902818,0.0005775041,0.006301415,0.0005477877,0.0000932513,0.00001628848,0.00003201075,0.0001321529,0.002017704],"genre_scores_gemma":[0.9975634,0.0001392041,0.001428999,0.0001132798,0.00001515746,0.000006492626,0.00003164466,0.00002869192,0.0006732495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003029404,"threshold_uncertainty_score":0.0101344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131645597693727,"score_gpt":0.2882042984415518,"score_spread":0.2768878424646146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}