{"id":"W2002734029","doi":"10.1038/nsmb.1978","title":"Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme","year":2011,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Allosteric regulation; Isothermal titration calorimetry; Allosteric enzyme; Biophysics; Chemistry; Circular dichroism; Folding (DSP implementation); Cooperative binding; Substrate (aquarium); Protein folding; Crystallography; Binding site; Enzyme; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002784766,0.0004041177,0.0003518766,0.0001821389,0.00008950695,0.00002480387,0.0006019319,0.001007318,0.00008139011],"category_scores_gemma":[0.0001305852,0.000352797,0.000200784,0.000387591,0.0002075068,0.000007127174,0.0004194567,0.0008500051,0.00001514746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003230132,"about_ca_system_score_gemma":0.00006386308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008062702,"about_ca_topic_score_gemma":0.00003019696,"domain_scores_codex":[0.9974042,0.0003046547,0.0003811498,0.0008933362,0.0001855044,0.000831139],"domain_scores_gemma":[0.9990885,0.00001083863,0.0001285565,0.0004947401,0.00009229781,0.0001850207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001616833,0.00002201008,0.000800997,0.00001858064,0.00007155046,0.00009332499,0.00004974354,0.000006710646,0.9938409,0.003690197,0.00001867873,0.001225583],"study_design_scores_gemma":[0.0007277337,0.0003378569,0.002196839,0.0000198912,0.00001642629,0.0001263152,0.00004959752,0.0001534862,0.9910784,0.004413288,0.0004068884,0.0004733274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926816,0.001826251,0.003656399,0.0001274776,0.0003546785,0.0003501863,0.00002109543,0.00003360554,0.0009486756],"genre_scores_gemma":[0.9929877,0.00004678765,0.005573703,0.0007605276,0.00007557031,0.00003051871,0.0003972559,0.00005338915,0.0000745588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002762591,"threshold_uncertainty_score":0.9998924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01131645597693727,"score_gpt":0.2882042984415518,"score_spread":0.2768878424646146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}