{"id":"W2002734325","doi":"10.1158/1535-7163.targ-13-c205","title":"Abstract C205: Cytotoxicity and target modulation in pediatric solid tumors by the proteasome inhibitor carfilzomib.","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital","funders":"","keywords":"Carfilzomib; Tolerability; Proteasome inhibitor; Cancer research; Proteasome; Cytotoxicity; Apoptosis; Pharmacology; Cell cycle; Cell culture; Chemistry; Medicine; In vitro; Biology; Adverse effect; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001766681,0.0004120531,0.0002968693,0.0002604585,0.0001494744,0.0002209556,0.0001816034,0.0002876403,0.001004422],"category_scores_gemma":[0.0001017581,0.00008662528,0.000133978,0.0003016522,0.0001657607,0.0001014327,0.000080331,0.0004133657,0.0003812586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005079984,"about_ca_system_score_gemma":0.0004556632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001718324,"about_ca_topic_score_gemma":0.002735623,"domain_scores_codex":[0.9998922,0.00001972857,0.000008732461,0.00001974093,0.00003019013,0.00002944006],"domain_scores_gemma":[0.9999393,0.00001454669,0.00001642973,0.000004394105,0.00001005109,0.00001522234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001455381,0.0003421949,0.00351215,0.0006223313,0.00002688457,0.0007151031,0.0000373413,0.0008601536,0.9636013,0.0001845392,0.001926572,0.02671597],"study_design_scores_gemma":[0.0002141523,0.004810803,0.02000662,0.00003477257,0.00006349944,0.00422204,0.00003676132,0.001444118,0.9543623,0.00006378617,0.01472942,0.00001180745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657999,0.02445573,0.001960381,0.0004911885,0.00008271659,0.000161569,0.00266863,0.0002327674,0.004147192],"genre_scores_gemma":[0.9836788,0.008515567,0.001982786,0.0001150261,0.0000558265,0.00008233236,0.003641898,0.00001333545,0.001914473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001718324,"threshold_uncertainty_score":0.003685772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01292518297111887,"score_gpt":0.2526142260824104,"score_spread":0.2396890431112915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}