{"id":"W2002743276","doi":"10.1021/jm9012455","title":"Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health; Ministère du Développement Économique, de l’Innovation et de l’Exportation","keywords":"Furin; Proprotein Convertases; Chemistry; Biochemistry; Proteases; Arginine; Serine; Proprotein convertase; Trypsin; Enzyme; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003004301,0.0001537511,0.0003022242,0.00003568465,0.00002871969,0.000006757966,0.0001127117,0.000169441,0.00002742605],"category_scores_gemma":[0.00006392672,0.0001280287,0.0001032631,0.00006178447,0.00006902609,0.000005198058,0.00001547171,0.0002235252,1.614459e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001442967,"about_ca_system_score_gemma":0.0001106102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005871667,"about_ca_topic_score_gemma":0.000001050766,"domain_scores_codex":[0.9988549,0.00001841766,0.0005207674,0.0001492467,0.0002961396,0.000160472],"domain_scores_gemma":[0.9991304,0.00000930723,0.0003814014,0.0001306874,0.0001874875,0.0001607255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005980246,0.00009229095,0.001961962,0.00009258062,0.00007257178,0.00009730028,0.00008261736,0.000009252347,0.9956109,0.000003115103,0.00006443993,0.00131496],"study_design_scores_gemma":[0.001695687,0.00129361,0.002259527,0.0001575493,0.0001707089,0.000445446,0.0003164959,0.00002661749,0.990919,0.00002630326,0.002550295,0.0001387799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944395,0.004218583,0.0006587519,0.0003122679,0.00007665545,0.00007902185,0.000004439388,0.000003476086,0.0002072489],"genre_scores_gemma":[0.99863,0.0004360431,0.0002804428,0.00009921278,0.0003313491,6.923449e-7,0.0001027998,0.00001020816,0.0001092759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004691905,"threshold_uncertainty_score":0.5220858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005326584119608576,"score_gpt":0.2138545671876985,"score_spread":0.2085279830680899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}