{"id":"W2002743276","doi":"10.1021/jm9012455","title":"Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health; Ministère du Développement Économique, de l’Innovation et de l’Exportation","keywords":"Furin; Proprotein Convertases; Chemistry; Biochemistry; Proteases; Arginine; Serine; Proprotein convertase; Trypsin; Enzyme; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001832374,0.0004521912,0.0003142618,0.0001972108,0.00009810249,0.000182586,0.0002697,0.0002014207,0.0005281163],"category_scores_gemma":[0.0001026784,0.0001203686,0.0002180965,0.0001705428,0.0001378356,0.0001580894,0.0001378634,0.0003767632,0.0002052659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000295368,"about_ca_system_score_gemma":0.0002182793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005011588,"about_ca_topic_score_gemma":0.00107944,"domain_scores_codex":[0.9998944,0.00002137273,0.000007946624,0.00001861322,0.00002599812,0.00003166879],"domain_scores_gemma":[0.9999501,0.000009855381,0.000012092,0.000004093269,0.000006619342,0.00001725781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004030908,0.0001948009,0.0001510227,0.0001140366,0.00002481855,0.000109023,0.00002302387,0.0010661,0.9883863,0.0004556114,0.000188751,0.008883357],"study_design_scores_gemma":[0.0003491891,0.003485354,0.001756436,0.00001378906,0.00004641783,0.0004234818,0.000009700503,0.00281055,0.9827182,0.0001074414,0.008266107,0.00001334894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757136,0.01131516,0.008245607,0.0001239702,0.00005853875,0.0002257487,0.0004862092,0.00009982461,0.003731356],"genre_scores_gemma":[0.9859828,0.004731706,0.005521831,0.0000655717,0.00001894672,0.0001014723,0.0006770981,0.00001133127,0.002889244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005281163,"threshold_uncertainty_score":0.002143085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005326584119608576,"score_gpt":0.2138545671876985,"score_spread":0.2085279830680899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}