{"id":"W2002774545","doi":"10.1074/jbc.m807261200","title":"The N-terminal Amphipathic α-Helix of Viperin Mediates Localization to the Cytosolic Face of the Endoplasmic Reticulum and Inhibits Protein Secretion","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; Yale University; Howard Hughes Medical Institute","keywords":"Endoplasmic reticulum; Secretion; Golgi apparatus; Cell biology; Secretory pathway; Biology; Secretory protein; Transport protein; Chemistry; Biochemistry; Molecular biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053378,0.0001867658,0.0002589473,0.0000811869,0.0001168631,0.000196999,0.0001502376,0.0001747947,0.0005880444],"category_scores_gemma":[0.000113307,0.00008555641,0.0001726576,0.00006836287,0.0001753716,0.0001539831,0.0002008538,0.0005245043,0.0002398336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002172459,"about_ca_system_score_gemma":0.0001292514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002333776,"about_ca_topic_score_gemma":0.0002152544,"domain_scores_codex":[0.9999067,0.00001745206,0.00001022748,0.00001894761,0.00002506331,0.00002167582],"domain_scores_gemma":[0.9998647,0.00002602443,0.00003759539,0.00001706454,0.00001792183,0.0000368024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003433926,0.000005648625,0.00006054207,0.00001206111,0.000001971461,0.00002464304,0.000003674183,0.00002855042,0.9994161,0.00003074408,0.000008304636,0.0003733286],"study_design_scores_gemma":[0.000009207261,0.0001539103,0.002550313,0.00000349347,0.00000668776,0.0001961942,0.00001025265,0.0006808903,0.9951501,0.00002411611,0.001212508,0.000002320913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947637,0.0009072944,0.003185074,0.00004857874,0.00001703912,0.00001448626,0.00009297807,0.0000400797,0.000930662],"genre_scores_gemma":[0.9954575,0.0004621886,0.002111943,0.00005266398,0.00000866795,0.00001455837,0.0003156192,0.00001536419,0.001561384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005880444,"threshold_uncertainty_score":0.001967132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159800952102424,"score_gpt":0.2280568777243446,"score_spread":0.2164588682033204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}