{"id":"W2002784005","doi":"10.1038/nature09999","title":"A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":380,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Vlaamse regering; Fonds Wetenschappelijk Onderzoek; Agentschap voor Innovatie door Wetenschap en Technologie; York University; National Cancer Institute; National Institutes of Health; Edward Mallinckrodt, Jr. Foundation; Memorial Sloan-Kettering Cancer Center; Irma T. Hirschl Trust; Alex's Lemonade Stand Foundation for Childhood Cancer; Howard Hughes Medical Institute","keywords":"Notch signaling pathway; HES1; Biology; Haematopoiesis; Cyclin-dependent kinase 8; Cancer research; Notch proteins; Stem cell; Myeloid; Cell biology; Cellular differentiation; Progenitor cell; Transcriptome; Signal transduction; Genetics; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001430559,0.0001681886,0.0001967405,0.0002127567,0.0002304204,0.0006983046,0.0003434938,0.0002993751,0.00146471],"category_scores_gemma":[0.000170751,0.00008979024,0.0001877042,0.0001376787,0.000236439,0.000288922,0.0003006396,0.0004497017,0.0005087485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00040693,"about_ca_system_score_gemma":0.0002321298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002708278,"about_ca_topic_score_gemma":0.0003991918,"domain_scores_codex":[0.9999348,0.000008287674,0.000008139219,0.00001204983,0.00002455826,0.00001216281],"domain_scores_gemma":[0.9999421,0.00001007867,0.00001094194,0.00001079739,0.000007118316,0.00001893134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003073163,0.00002233039,0.0009847858,0.00005765642,0.00001261755,0.002052835,0.00003082778,0.0002876787,0.9805632,0.004614597,0.0002620027,0.01080412],"study_design_scores_gemma":[0.0001952443,0.0004711196,0.01307234,0.00002801629,0.00008978031,0.02418342,0.0001399742,0.005915358,0.9081541,0.004011676,0.04371218,0.00002680714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822102,0.004186123,0.005582487,0.0004514405,0.0001233161,0.00002872917,0.0003826952,0.0001052759,0.006929823],"genre_scores_gemma":[0.9951376,0.0008341108,0.001403268,0.00008363403,0.000017989,0.000006431297,0.0002250384,0.00001299484,0.002278914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00146471,"threshold_uncertainty_score":0.004899919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03378567249484475,"score_gpt":0.2885894207259861,"score_spread":0.2548037482311413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}