{"id":"W2002800705","doi":"10.1128/aac.02729-14","title":"Effects of the W153L Substitution in HIV Reverse Transcriptase on Viral Replication and Drug Resistance to Multiple Categories of Reverse Transcriptase Inhibitors","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada); McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute for Health and Care Research","keywords":"Reverse transcriptase; Virology; Biology; RNase H; Nevirapine; Viral replication; Nucleotidyltransferase; Lentivirus; Reverse-transcriptase inhibitor; Enzyme; Nucleoside Reverse Transcriptase Inhibitor; Virus; Genetics; RNA; Biochemistry; Gene; Viral load; Viral disease; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002780904,0.0004742929,0.0004806061,0.0002362299,0.0001510579,0.0004456989,0.0003121515,0.0004542964,0.001390108],"category_scores_gemma":[0.0003927903,0.0002400567,0.0004787167,0.0002527483,0.0003311741,0.0002042102,0.000294712,0.0005332179,0.0003369066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002958273,"about_ca_system_score_gemma":0.0002598277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001101856,"about_ca_topic_score_gemma":0.0009981418,"domain_scores_codex":[0.999648,0.00008458137,0.00007982666,0.00005424354,0.00007566924,0.00005763214],"domain_scores_gemma":[0.9997202,0.00007924448,0.0001022992,0.00002655581,0.00002253569,0.00004921373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000453732,0.0001849653,0.0006965022,0.00003294677,0.00003602718,0.0003330621,0.00002448819,0.0003360225,0.9949219,0.0001523451,0.00004601022,0.00278195],"study_design_scores_gemma":[0.0001250744,0.003108588,0.006097892,0.00002452653,0.00009295875,0.001462564,0.00005813227,0.002679416,0.9841717,0.0000608685,0.002096846,0.00002149992],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986209,0.0003605003,0.0003293135,0.00004085305,0.00001378765,0.00002267755,0.0001084634,0.00002002885,0.0004835606],"genre_scores_gemma":[0.9978656,0.0002934736,0.0009753846,0.00006524568,0.000007454607,0.00001730135,0.0002083152,0.00002255644,0.0005445371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001390108,"threshold_uncertainty_score":0.004650354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005481747144956179,"score_gpt":0.2154444643764787,"score_spread":0.2099627172315225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}