{"id":"W2002858846","doi":"10.1042/bj20060968","title":"The Walker B motif of the second nucleotide-binding domain (NBD2) of CFTR plays a key role in ATPase activity by the NBD1–NBD2 heterodimer","year":2006,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Walker motifs; ATP hydrolysis; Cyclic nucleotide-binding domain; Cystic fibrosis transmembrane conductance regulator; Chemistry; Nucleotide; ATP-binding cassette transporter; ATPase; Transmembrane domain; Biochemistry; Binding site; Linker; Amino acid; Transporter; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007871442,0.0001751374,0.0003325671,0.0000581912,0.0001958848,0.0000436116,0.0004614874,0.0001012124,0.0001833602],"category_scores_gemma":[0.0004597119,0.00008189821,0.0002328516,0.0002945053,0.0006129454,0.00008723889,0.0001728191,0.0008916921,0.000006301087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001530017,"about_ca_system_score_gemma":0.00012539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008488815,"about_ca_topic_score_gemma":0.00005234056,"domain_scores_codex":[0.9978087,0.0002306547,0.0005225035,0.0002004205,0.0007753246,0.0004624315],"domain_scores_gemma":[0.9983634,0.0006600074,0.0003151971,0.0004168755,0.0001106041,0.0001338875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006080345,0.0002127067,0.006842044,0.00003837393,0.00004555575,0.000008768984,0.0001095095,0.000006373636,0.9780794,0.00002763656,0.01302666,0.0009948792],"study_design_scores_gemma":[0.001663304,0.0001116183,0.02364905,0.0002151318,0.00002729547,0.0001883752,0.0002445253,0.0001214793,0.9662787,0.0008567215,0.006545413,0.00009840952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948857,0.001624898,0.00004732329,0.002340411,0.00008888982,0.0003049932,0.00005664942,0.000005846358,0.0006452464],"genre_scores_gemma":[0.99887,0.00004584833,0.0003232386,0.00005314309,0.0001718692,0.000007717362,0.000003271881,0.00002158466,0.0005033733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01680701,"threshold_uncertainty_score":0.3874008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006435526062374035,"score_gpt":0.2549575191928259,"score_spread":0.2485219931304519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}