{"id":"W2002858846","doi":"10.1042/bj20060968","title":"The Walker B motif of the second nucleotide-binding domain (NBD2) of CFTR plays a key role in ATPase activity by the NBD1–NBD2 heterodimer","year":2006,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Walker motifs; ATP hydrolysis; Cyclic nucleotide-binding domain; Cystic fibrosis transmembrane conductance regulator; Chemistry; Nucleotide; ATP-binding cassette transporter; ATPase; Transmembrane domain; Biochemistry; Binding site; Linker; Amino acid; Transporter; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001678901,0.0004506986,0.0004934333,0.0001572112,0.000183287,0.0003168148,0.0002388485,0.0004501235,0.001758585],"category_scores_gemma":[0.0001902101,0.0001519632,0.000346006,0.0001825592,0.0002187896,0.0002200364,0.0002802193,0.0003421463,0.001060572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002139179,"about_ca_system_score_gemma":0.0001955149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004619734,"about_ca_topic_score_gemma":0.000441393,"domain_scores_codex":[0.9998094,0.00003999514,0.00001772943,0.0000598644,0.00005018399,0.00002280817],"domain_scores_gemma":[0.9998947,0.00001640451,0.00002926353,0.000009723597,0.000009002561,0.0000407685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001353725,0.00001928667,0.0006830158,0.00005095691,0.000006561477,0.0001462058,0.00001524443,0.00003632111,0.9974426,0.0001550266,0.00005586939,0.001253618],"study_design_scores_gemma":[0.00006174337,0.0003234426,0.01615231,0.00002558741,0.00003021238,0.003865077,0.00008280019,0.002349708,0.9617916,0.000180132,0.01511283,0.00002449012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894499,0.00282383,0.005779451,0.000124802,0.00006344991,0.0000272449,0.0002906981,0.0001097789,0.001330862],"genre_scores_gemma":[0.990985,0.0006860912,0.005019045,0.00007277577,0.00001533149,0.00002846306,0.0008548609,0.00002307661,0.002315304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001758585,"threshold_uncertainty_score":0.005883038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006435526062374035,"score_gpt":0.2549575191928259,"score_spread":0.2485219931304519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}