{"id":"W2002874740","doi":"10.1111/j.1471-4159.2006.04184.x","title":"Ubiquitin–proteasome pathway mediates degradation of APH‐1","year":2006,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia; Mount Sinai Hospital","funders":"","keywords":"Lactacystin; Proteasome; Nicastrin; Presenilin; Ubiquitin; Protein degradation; Proteolysis; Cell biology; Biology; Amyloid precursor protein; Transmembrane protein; Biochemistry; Chemistry; Proteasome inhibitor; Alzheimer's disease; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009767414,0.0004599006,0.0002547025,0.0001769315,0.0001973031,0.0003467559,0.0001127517,0.0001930255,0.001505852],"category_scores_gemma":[0.0000753019,0.0001161489,0.0002891733,0.00009170661,0.0001163836,0.0002122224,0.0001985752,0.000406487,0.0008031926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003912665,"about_ca_system_score_gemma":0.000238619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003986632,"about_ca_topic_score_gemma":0.0004057322,"domain_scores_codex":[0.9998963,0.00001217341,0.000009352586,0.0000256785,0.00002785153,0.00002862686],"domain_scores_gemma":[0.9999585,0.000005140724,0.00001003286,0.000006125236,0.000008167981,0.00001193088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006989048,0.00001933508,0.0001211057,0.00007536451,0.000007698148,0.00008642834,0.000008560773,0.00002423535,0.997273,0.0001363838,0.0001180451,0.002059842],"study_design_scores_gemma":[0.00001681146,0.0001342084,0.004672934,0.00001002075,0.00001513272,0.0004154302,0.00001134497,0.0006047919,0.9883504,0.0001311211,0.00563329,0.00000458265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9524148,0.0316954,0.006469354,0.0003390352,0.0002364832,0.00007092649,0.001089381,0.0003368356,0.007347876],"genre_scores_gemma":[0.9812186,0.007040278,0.002038079,0.00008755406,0.00004092602,0.00004490195,0.0009795809,0.00001580744,0.008534223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001505852,"threshold_uncertainty_score":0.005037546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668089709275581,"score_gpt":0.2760193536290381,"score_spread":0.2593384565362822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}