{"id":"W2002900184","doi":"10.1016/s0005-2736(03)00228-1","title":"Mutation of proline residues in the NH2-terminal region of the multidrug resistance protein, MRP1 (ABCC1): effects on protein expression, membrane localization, and transport function","year":2003,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canada Research Chairs","keywords":"Mutant; ABCC1; Transmembrane domain; Transmembrane protein; Biology; Amino acid; Molecular biology; Alanine; Wild type; ATP-binding cassette transporter; Transport protein; Biochemistry; Chemistry; Gene; Transporter; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002329512,0.0006200469,0.0003575158,0.000217755,0.0002836512,0.0003721437,0.0004104676,0.0007714961,0.00179204],"category_scores_gemma":[0.0003453207,0.000300887,0.0004616771,0.0002945845,0.0005681647,0.0003169194,0.0002752754,0.0008983702,0.0006942033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000423812,"about_ca_system_score_gemma":0.0003060084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008834288,"about_ca_topic_score_gemma":0.000839386,"domain_scores_codex":[0.9997808,0.00005833237,0.00004804907,0.00004047195,0.00003261787,0.00003973547],"domain_scores_gemma":[0.9994407,0.0002032785,0.0001769151,0.00005051074,0.00003765371,0.00009091404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006981384,0.00009586541,0.0001540742,0.00006106496,0.00001753782,0.0005209669,0.00003386892,0.0001888443,0.997166,0.0001673829,0.00005153846,0.0008446621],"study_design_scores_gemma":[0.0001425483,0.0004988051,0.002657115,0.0000122849,0.00007931005,0.00169267,0.00005071014,0.001369162,0.9914184,0.00008547911,0.00197344,0.00002018998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962179,0.000672854,0.001807029,0.0001885169,0.00005456771,0.00003811686,0.0003482667,0.0000506082,0.0006221467],"genre_scores_gemma":[0.9959008,0.000545217,0.001593026,0.00008008615,0.00002610029,0.00002630933,0.0004458458,0.00005623378,0.001326292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00179204,"threshold_uncertainty_score":0.005994976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008156219560586223,"score_gpt":0.2244451621858927,"score_spread":0.2162889426253065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}