{"id":"W2002937040","doi":"10.1371/journal.pmed.0020073","title":"Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain","year":2005,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":3526,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Washington University in St. Louis; Genentech; AstraZeneca; LUNGevity Foundation; Memorial Sloan-Kettering Cancer Center; CHEST Foundation; Canadian Institutes of Health Research; American Cancer Society","keywords":"Gefitinib; Erlotinib; T790M; Cancer research; Epidermal growth factor receptor; Lung cancer; Resistance mutation; Medicine; Mutation; Erlotinib Hydrochloride; Tyrosine kinase; Tyrosine-kinase inhibitor; Biology; Cancer; Oncology; Internal medicine; Genetics; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164093,0.0002965828,0.0002671235,0.0002760531,0.0002540222,0.0002724581,0.0002522921,0.0004597965,0.001484509],"category_scores_gemma":[0.0006550774,0.0000923577,0.0002556081,0.0001871441,0.0002525017,0.0001306678,0.0001913674,0.0003367739,0.0002661922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003630186,"about_ca_system_score_gemma":0.0002306617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004767694,"about_ca_topic_score_gemma":0.0007947451,"domain_scores_codex":[0.9998302,0.00001734514,0.0000251662,0.0000452514,0.00004569177,0.00003631783],"domain_scores_gemma":[0.9996191,0.00007130273,0.0001380056,0.00002434023,0.00004833758,0.00009886186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001477603,0.000409708,0.6319259,0.0002683172,0.0001867756,0.03221686,0.0003003497,0.0005687736,0.3026921,0.0002168362,0.0005965678,0.02914026],"study_design_scores_gemma":[0.0001985777,0.002614668,0.6674749,0.00002812357,0.0002113912,0.2595544,0.000147666,0.001537243,0.06511209,0.0001093202,0.002991286,0.00002032866],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988116,0.0003116082,0.0001984032,0.00003433441,0.000003120052,0.000007850275,0.00003695584,0.00001315687,0.0005829762],"genre_scores_gemma":[0.999522,0.00006604558,0.0001604102,0.00001752165,0.000006879673,0.000003447579,0.00008196609,0.000002064451,0.0001395959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001484509,"threshold_uncertainty_score":0.004966199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02397308457094872,"score_gpt":0.3131054173142422,"score_spread":0.2891323327432935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}