{"id":"W2002947836","doi":"10.1006/clim.2000.4956","title":"Mutations in Activation-Induced Cytidine Deaminase in Patients with Hyper IgM Syndrome","year":2000,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":144,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; American Lebanese Syrian Associated Charities","keywords":"Cytidine deaminase; Immunoglobulin M; Activation-induced (cytidine) deaminase; Neutropenia; Immunology; Medicine; Somatic hypermutation; Biology; Antibody; Internal medicine; Immunoglobulin G; B cell; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000356915,0.001786144,0.0005801567,0.002711853,0.001065116,0.0008161429,0.0006889054,0.001907286,0.002657214],"category_scores_gemma":[0.002915559,0.0004171736,0.0004570971,0.00139779,0.001022669,0.0006013431,0.0005412187,0.0007729137,0.000315362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005372364,"about_ca_system_score_gemma":0.0005158276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002280031,"about_ca_topic_score_gemma":0.00126936,"domain_scores_codex":[0.9994585,0.00008613075,0.0001001185,0.0001014967,0.0001180426,0.0001357813],"domain_scores_gemma":[0.9983986,0.0007150327,0.0004003359,0.00005752083,0.0001156591,0.0003128172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001418765,0.0002123729,0.555804,0.0001057621,0.0001429622,0.3983964,0.001154121,0.0005898459,0.03165717,0.0006679316,0.0007733735,0.009077253],"study_design_scores_gemma":[0.0001368434,0.000604327,0.3792427,0.00005011344,0.0002242913,0.6106008,0.0007752463,0.001267571,0.005444571,0.0004951688,0.001107962,0.00005022205],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969068,0.0004111648,0.0002390299,0.0002446201,0.00002862514,0.00001735201,0.0001022016,0.00003056176,0.002019658],"genre_scores_gemma":[0.9995002,0.00008448149,0.0001134984,0.00006743897,0.00004051839,0.00000497711,0.00004160461,0.000005293833,0.0001419796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002711853,"threshold_uncertainty_score":0.008889258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01450741237028155,"score_gpt":0.2674422797420222,"score_spread":0.2529348673717406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}