{"id":"W2002973721","doi":"10.1073/pnas.0501559102","title":"Decline in skeletal muscle mitochondrial function with aging in humans","year":2005,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1308,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging","keywords":"Mitochondrial DNA; Mitochondrion; Skeletal muscle; Biology; Oxidative phosphorylation; Oxidative damage; 8-Hydroxy-2'-deoxyguanosine; Oxidative stress; Internal medicine; Endocrinology; Genetics; DNA oxidation; Biochemistry; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000290256,0.0001624129,0.000284317,0.0004756604,0.0001479475,0.0002469582,0.00009351429,0.0001964241,0.0007315892],"category_scores_gemma":[0.0007412922,0.00006829204,0.0000794339,0.0002980712,0.0001733847,0.0002157909,0.0001476053,0.0001482396,0.0002196053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001129388,"about_ca_system_score_gemma":0.00006634455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007950391,"about_ca_topic_score_gemma":0.0006282913,"domain_scores_codex":[0.9999125,0.00002065775,0.000008937519,0.00002559859,0.00002279263,0.00000956099],"domain_scores_gemma":[0.9998214,0.00002557352,0.00006570007,0.00001514086,0.00004407177,0.00002814472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001013205,0.0001199153,0.8587931,0.0001948688,0.000192683,0.00110201,0.0006119906,0.0003465414,0.02704378,0.0002000814,0.001311815,0.10907],"study_design_scores_gemma":[0.000008823958,0.0003791198,0.9946979,0.00001522756,0.00003557314,0.001936604,0.00008885159,0.000136009,0.0009676312,0.0001686708,0.001561106,0.000004437125],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916952,0.006250463,0.0006868282,0.00008999483,0.0000124577,0.00000723465,0.0002382669,0.00002249875,0.0009970553],"genre_scores_gemma":[0.9969925,0.001820084,0.0004315377,0.00007552294,0.0000246819,0.00000494028,0.0002131762,0.000003301611,0.0004341497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007950391,"threshold_uncertainty_score":0.002447426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02134362516071654,"score_gpt":0.2842484869768334,"score_spread":0.2629048618161168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}