{"id":"W2002979500","doi":"10.1074/jbc.m109.019877","title":"Chemical Genetic Profiling and Characterization of Small-molecule Compounds That Affect the Biosynthesis of Unsaturated Fatty Acids in Candida albicans","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Candida albicans; Fatty acid; Biochemistry; Biology; Virulence; Unsaturated fatty acid; Fatty acid desaturase; Corpus albicans; Gene; Microbiology; Polyunsaturated fatty acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001245605,0.0003734441,0.0003197528,0.0007043637,0.0001761014,0.0003915573,0.0002885792,0.0003323446,0.0007810188],"category_scores_gemma":[0.0002055383,0.0001464707,0.0004184022,0.0006702669,0.0001423452,0.0001414907,0.0001604265,0.0004552425,0.0002572457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003611635,"about_ca_system_score_gemma":0.0004594772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003173005,"about_ca_topic_score_gemma":0.004046516,"domain_scores_codex":[0.9997992,0.0000133856,0.00002172792,0.00003094523,0.0001049808,0.00002975851],"domain_scores_gemma":[0.9997905,0.00002814052,0.00004966607,0.00001840481,0.00007685422,0.00003639071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005028523,0.00002989166,0.0001886181,0.00001941912,0.000003795875,0.00002769812,0.000002651627,0.0001641411,0.9984339,0.00003090315,0.00002273465,0.001025955],"study_design_scores_gemma":[0.00001425542,0.0003434573,0.00777404,0.000008660099,0.00002424277,0.0001293091,0.00003109317,0.001116205,0.9891811,0.00004098913,0.001326845,0.000009828022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854339,0.001338263,0.004774522,0.0001823197,0.00003610913,0.0001433713,0.005550037,0.0001272213,0.002414235],"genre_scores_gemma":[0.9726917,0.001838972,0.01124771,0.000237306,0.00001775834,0.0001681273,0.00897304,0.00006322957,0.004762245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003173005,"threshold_uncertainty_score":0.006309032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02518396215081241,"score_gpt":0.2595004932710544,"score_spread":0.234316531120242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}