{"id":"W2002991724","doi":"10.1210/me.2010-0005","title":"Conformation of the Mineralocorticoid Receptor N-terminal Domain: Evidence for Induced and Stable Structure","year":2010,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Directorate for Biological Sciences; University of Aberdeen; Imperial College London","keywords":"Transactivation; Biology; Mineralocorticoid receptor; Coactivator; Nuclear receptor; Protein folding; Protein structure; Context (archaeology); Cell biology; Plasma protein binding; Binding site; Receptor; Biophysics; Biochemistry; Gene; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004030179,0.00007258966,0.0001590071,0.00004707781,0.00004502845,0.000003925417,0.00005344889,0.00007326934,0.00004159526],"category_scores_gemma":[0.0002883211,0.00004811148,0.00004478376,0.00005711537,0.00008816631,0.00004492833,0.00003484057,0.0001401088,0.000001195121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009175053,"about_ca_system_score_gemma":0.0000633312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001996885,"about_ca_topic_score_gemma":0.00001875318,"domain_scores_codex":[0.9994459,0.00002053228,0.000168659,0.0001108637,0.0001108432,0.0001431832],"domain_scores_gemma":[0.9994769,0.00004037662,0.0001045776,0.0001927606,0.0001409637,0.00004438218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001212416,0.00001036801,0.002513343,0.00003495434,0.00001415663,0.00000761055,0.00006837843,7.353801e-7,0.9864957,0.004644441,0.0001113723,0.005977726],"study_design_scores_gemma":[0.001720335,0.0003350418,0.1137289,0.00005123936,0.00007911928,0.00112913,0.00006232971,0.0003654491,0.8668016,0.0009554277,0.01467396,0.00009746112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963941,0.0001451983,0.0002969863,0.002483668,0.0001603398,0.000411087,0.000004862793,0.000009490728,0.00009425575],"genre_scores_gemma":[0.9969724,0.00000957393,0.002388342,0.0004910246,0.00003285597,0.00001191868,0.000008523624,0.000007045346,0.00007835824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1196941,"threshold_uncertainty_score":0.1961929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02896522221638259,"score_gpt":0.3008030624078048,"score_spread":0.2718378401914222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}