{"id":"W2003020245","doi":"10.1101/gad.1234304","title":"A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation","year":2004,"lang":"en","type":"article","venue":"Genes & Development","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Public Health Service; National Institutes of Health","keywords":"MyoD; Myogenesis; Mef2; Biology; MyoD Protein; Gene expression; Myogenic regulatory factors; Regulation of gene expression; PITX2; Cell biology; Cellular differentiation; Gene isoform; Gene; Myocyte; Molecular biology; Homeobox; Genetics; Enhancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001352086,0.0003051269,0.0003055047,0.0001836112,0.0001727765,0.0003816532,0.0002806433,0.0002608591,0.001127614],"category_scores_gemma":[0.00019286,0.0002557088,0.0002134304,0.000101345,0.0003372056,0.0003272649,0.000539529,0.0005037227,0.0003243391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005821405,"about_ca_system_score_gemma":0.0002780842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002956272,"about_ca_topic_score_gemma":0.000643539,"domain_scores_codex":[0.9998467,0.00001623492,0.000008120144,0.00005115988,0.00004837538,0.00002937002],"domain_scores_gemma":[0.999916,0.00001509065,0.00001730901,0.00001111993,0.00001704342,0.00002348303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001372796,0.00001845128,0.0002573407,0.00004429867,0.000004860538,0.00009643476,0.00001608091,0.0002266361,0.9938017,0.0006812986,0.00005968187,0.004655971],"study_design_scores_gemma":[0.00009243972,0.0003954344,0.009261898,0.00003275986,0.00003032082,0.0004308027,0.00005235081,0.009427939,0.9731418,0.001283534,0.005831707,0.00001902511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9359497,0.00320667,0.05284731,0.0006463452,0.0002147927,0.00007962094,0.0004284587,0.0006986163,0.005928508],"genre_scores_gemma":[0.9817193,0.0008437869,0.0119777,0.0001634552,0.00002599697,0.00005965824,0.0002149021,0.00002946059,0.004965727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001127614,"threshold_uncertainty_score":0.004223764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009414012541356648,"score_gpt":0.213261194276747,"score_spread":0.2038471817353903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}