{"id":"W2003026619","doi":"10.1021/np800544b","title":"Lipidyl Pseudopteranes A−F: Isolation, Biomimetic Synthesis, and PTP1B Inhibitory Activity of a New Class of Pseudopteranoids from the Gorgonian <i>Pseudopterogorgia acerosa</i>","year":2008,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Prince Edward Island","funders":"","keywords":"Gorgonian; Diterpene; Moiety; Chemistry; Stereochemistry; Coral; Biochemistry; Biology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003403086,0.000250288,0.00045523,0.00007804374,0.00009807404,0.0000205396,0.0003817457,0.0001466223,0.000007354321],"category_scores_gemma":[0.0008882882,0.0001734586,0.0001543801,0.0002115628,0.000347594,0.00005334652,0.0001470361,0.0002922286,0.000001058776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001879736,"about_ca_system_score_gemma":0.0002975306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001016016,"about_ca_topic_score_gemma":0.000008889748,"domain_scores_codex":[0.9983829,0.0001632296,0.0005994327,0.0003075343,0.0003366638,0.0002102837],"domain_scores_gemma":[0.9979706,0.0001251262,0.0008926136,0.0004638399,0.0004526943,0.00009509733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008422838,0.0001007025,0.005478293,0.00005919965,0.0001733663,0.00000762649,0.0001802178,0.00001129944,0.9822267,0.00001200139,0.006109008,0.004799357],"study_design_scores_gemma":[0.0008273571,0.0003525989,0.0318635,0.0001369477,0.00008944875,0.000253563,0.00001998402,0.00001660353,0.9643214,0.00004317319,0.00190529,0.0001700719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9540407,0.04302504,0.00007855055,0.002091672,0.000468822,0.0002301062,0.00004887953,0.000004742409,0.00001145532],"genre_scores_gemma":[0.9937778,0.001464112,0.003517407,0.0001216781,0.001017305,0.000002381905,0.00001056298,0.00002295023,0.00006579913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04156093,"threshold_uncertainty_score":0.7073437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139747446148416,"score_gpt":0.2204525005350796,"score_spread":0.2090550260735955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}