{"id":"W2003026619","doi":"10.1021/np800544b","title":"Lipidyl Pseudopteranes A−F: Isolation, Biomimetic Synthesis, and PTP1B Inhibitory Activity of a New Class of Pseudopteranoids from the Gorgonian <i>Pseudopterogorgia acerosa</i>","year":2008,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Prince Edward Island","funders":"","keywords":"Gorgonian; Diterpene; Moiety; Chemistry; Stereochemistry; Coral; Biochemistry; Biology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006722642,0.0003349364,0.0001458896,0.0001858657,0.00008987813,0.0002036775,0.0001019818,0.0001734252,0.0004369361],"category_scores_gemma":[0.00009920767,0.00006965303,0.0001478631,0.0001429707,0.0001587733,0.0001992773,0.0001837105,0.000213808,0.000155212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001305625,"about_ca_system_score_gemma":0.0002176834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006202393,"about_ca_topic_score_gemma":0.001080338,"domain_scores_codex":[0.9999756,0.000003203191,0.000002721273,0.000005267437,0.000006553387,0.000006651163],"domain_scores_gemma":[0.999951,0.000005031289,0.00001534374,0.000005982649,0.000006546225,0.00001605529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001173271,0.00001334102,0.0004440162,0.00005775254,0.000004655282,0.00009809217,0.00002206109,0.00009955569,0.9942411,0.00006470142,0.00001503713,0.004822428],"study_design_scores_gemma":[0.00006107108,0.0007935312,0.01291414,0.00001123337,0.00002826017,0.0007800967,0.00006604832,0.0004274718,0.9792453,0.0001065535,0.005552885,0.00001343277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942452,0.002384644,0.002037546,0.0000560173,0.00001235222,0.00003724755,0.0003373802,0.00001694636,0.0008726644],"genre_scores_gemma":[0.992156,0.001953307,0.004151243,0.0000432127,0.000009462645,0.0000224667,0.0005512704,0.000007047865,0.001106033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006202393,"threshold_uncertainty_score":0.001461685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139747446148416,"score_gpt":0.2204525005350796,"score_spread":0.2090550260735955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}