{"id":"W2003082286","doi":"10.1371/journal.pone.0119372","title":"CRISPR MultiTargeter: A Web Tool to Find Common and Unique CRISPR Single Guide RNA Targets in a Set of Similar Sequences","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Genome Atlantic","keywords":"CRISPR; Cas9; Biology; Genome editing; Guide RNA; Subgenomic mRNA; Genetics; Computational biology; Gene; CRISPR interference; Genome; Genome engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007216838,0.001468367,0.001160444,0.001893181,0.0006493234,0.0008269228,0.00165971,0.001292153,0.01442161],"category_scores_gemma":[0.0008000653,0.0008387095,0.0009544558,0.0007672533,0.0003174183,0.0010845,0.001415904,0.001380931,0.008852345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004038808,"about_ca_system_score_gemma":0.0006344731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000588161,"about_ca_topic_score_gemma":0.001285355,"domain_scores_codex":[0.9994013,0.00008054313,0.00006160232,0.0001679704,0.0002237023,0.00006478337],"domain_scores_gemma":[0.9996275,0.0001309292,0.00006663807,0.00006301732,0.00004636819,0.00006559154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001552431,0.0007405978,0.005010266,0.00193351,0.0004391771,0.002016021,0.0003447779,0.008334726,0.5470554,0.005905513,0.07327435,0.3533933],"study_design_scores_gemma":[0.0004621184,0.0006779185,0.006343069,0.0001926137,0.0001827256,0.003175068,0.00009573576,0.08626175,0.665774,0.005470532,0.2310092,0.0003552557],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"software","genre_scores_codex":[0.03383311,0.001065754,0.6255489,0.0002226567,0.0001683032,0.0006268898,0.01083806,0.3192447,0.008451601],"genre_scores_gemma":[0.09566184,0.0007573199,0.8441908,0.0005642157,0.00003953918,0.001327946,0.02547206,0.01354891,0.01843751],"genre_candidate":"software","genre_consensus":null,"teacher_disagreement_score":0.01442161,"threshold_uncertainty_score":0.04824507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03865644930724763,"score_gpt":0.3001750169272018,"score_spread":0.2615185676199542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}