{"id":"W2003179893","doi":"10.1093/nar/gkr030","title":"Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly","year":2011,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; McGill University; National Heart, Lung, and Blood Institute; National Natural Science Foundation of China; National Cancer Institute; National Institutes of Health; National Science Foundation","keywords":"Biology; Mef2; Enhancer; Transcription factor; Genetics; Transcription (linguistics); DNA; DNA-binding protein; Cell biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004427609,0.0001355073,0.000227637,0.0001453969,0.00006842973,0.00001274273,0.0005405667,0.0002157558,0.0001486262],"category_scores_gemma":[0.0001630134,0.000124901,0.00008114811,0.0002191118,0.0001131439,0.000002983831,0.0003056263,0.0001783647,0.0000189482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002467968,"about_ca_system_score_gemma":0.0001076065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004370977,"about_ca_topic_score_gemma":0.0000356565,"domain_scores_codex":[0.9984704,0.0001121714,0.0002914892,0.0003472824,0.0004108471,0.0003678452],"domain_scores_gemma":[0.9987655,0.00002118739,0.00009011371,0.0006686804,0.0003262339,0.0001283225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00013475,0.00008151045,0.000154267,0.00006262033,0.00004496282,0.00000193717,0.0002833481,0.000003679266,0.9911094,0.006919739,0.0004504913,0.0007532419],"study_design_scores_gemma":[0.0002527902,0.001673712,0.002855233,0.00003750699,0.000005839669,0.00000354651,0.0001363748,0.00004170281,0.988322,0.006163411,0.0003833089,0.000124621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943867,0.00004427982,0.0002140932,0.00005324797,0.00006937303,0.0002899569,0.00008709874,0.00000441484,0.004850821],"genre_scores_gemma":[0.996444,0.00005371649,0.002645717,0.00006151207,0.00006739325,0.000008999808,0.00002264282,0.0000333159,0.0006627452],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004188075,"threshold_uncertainty_score":0.5093315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02987221054777155,"score_gpt":0.3064722882455694,"score_spread":0.2766000776977978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}