{"id":"W2003225189","doi":"10.1016/j.phrs.2006.04.001","title":"Vasorelaxant effects of harmine and harmaline extracted from Peganum harmala L. seed's in isolated rat aorta","year":2006,"lang":"en","type":"article","venue":"Pharmacological Research","topic":"Synthesis and bioactivity of alkaloids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Harmaline; Harmine; Pharmacology; Chemistry; IBMX; Diltiazem; Alkaloid; Phosphodiesterase; Biochemistry; Stereochemistry; Calcium; Medicine; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008742134,0.0001995051,0.000312512,0.0001329565,0.00008699899,0.0000344357,0.0002743207,0.0002527943,0.0002343358],"category_scores_gemma":[0.0004048824,0.0001597409,0.0000814271,0.000279201,0.0003415163,0.0000116747,0.0002978552,0.0004621832,0.00001263413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002016738,"about_ca_system_score_gemma":0.00006080359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000640361,"about_ca_topic_score_gemma":0.00007199725,"domain_scores_codex":[0.9976785,0.0005166878,0.0003389554,0.0005464007,0.0003831993,0.0005363185],"domain_scores_gemma":[0.9988623,0.0005601532,0.00007938555,0.0001788343,0.0001669298,0.0001524327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007878951,0.0007569381,0.02204081,0.00003851972,0.00005790995,0.00008521225,0.0000131703,0.000008041454,0.9716179,0.000009751003,0.002272915,0.002310894],"study_design_scores_gemma":[0.001535078,0.0004249932,0.1044355,0.00002725821,0.00002864042,0.000005315212,0.00001833828,0.0008840645,0.8882135,0.00009598905,0.004155541,0.0001757635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958299,0.002478739,0.0000961032,0.0006700057,0.0001030518,0.0004493889,0.00002927111,0.00001519734,0.0003283809],"genre_scores_gemma":[0.99752,0.001253208,0.0002214201,0.0001045457,0.0002940339,0.00005307645,0.00009716644,0.00001911792,0.0004374341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08340441,"threshold_uncertainty_score":0.6514043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02633382913759443,"score_gpt":0.3468768865848358,"score_spread":0.3205430574472414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}