{"id":"W2003237453","doi":"10.4161/epi.23416","title":"SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal","year":2013,"lang":"en","type":"article","venue":"Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Biology; Embryonic stem cell; Histone; Chromatin; Cellular differentiation; Lysine; Cell biology; Retinoic acid; Stem cell; Methyltransferase; Acetylation; Methylation; Histone H3; Histone methyltransferase; Epigenetics; Genetics; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008295059,0.0002584915,0.0001984637,0.0002358854,0.0002679491,0.0002907595,0.000243817,0.0001833741,0.001662635],"category_scores_gemma":[0.0001175838,0.0001455618,0.0002610061,0.0001780006,0.0001995201,0.0001523794,0.0003630769,0.0002895126,0.0006282961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003197939,"about_ca_system_score_gemma":0.0001972394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005149606,"about_ca_topic_score_gemma":0.00124731,"domain_scores_codex":[0.9998685,0.00001443611,0.00001330393,0.00003067952,0.0000551095,0.00001796953],"domain_scores_gemma":[0.9999037,0.000009210641,0.00002694404,0.00001374823,0.00001548822,0.00003086381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004549938,0.000006372263,0.001219779,0.00003379705,0.000008468366,0.00005995194,0.00001323683,0.00005416599,0.99591,0.0001318114,0.00003896652,0.002478012],"study_design_scores_gemma":[0.000003602719,0.00004729752,0.0102158,0.00000313227,0.0000101033,0.0002993363,0.00002059614,0.0002898759,0.9850762,0.00005458935,0.003975583,0.000003820953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796205,0.004378809,0.0100927,0.0001558003,0.00007179814,0.00002606402,0.001625456,0.000177497,0.003851326],"genre_scores_gemma":[0.9906466,0.0009125588,0.002608409,0.00004000154,0.000007944865,0.00001526994,0.001903068,0.00002224214,0.003843981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001662635,"threshold_uncertainty_score":0.005562067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246902512725807,"score_gpt":0.236104140352317,"score_spread":0.223635115225059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}