{"id":"W2003237453","doi":"10.4161/epi.23416","title":"SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal","year":2013,"lang":"en","type":"article","venue":"Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Biology; Embryonic stem cell; Histone; Chromatin; Cellular differentiation; Lysine; Cell biology; Retinoic acid; Stem cell; Methyltransferase; Acetylation; Methylation; Histone H3; Histone methyltransferase; Epigenetics; Genetics; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002322136,0.0001870063,0.0001858776,0.00003820355,0.0001042629,0.0000321042,0.0002015983,0.0001557933,0.00001516234],"category_scores_gemma":[0.00002910567,0.0001402397,0.0000995228,0.00008574779,0.00008885899,0.000003126112,0.00008803717,0.000061515,0.000007609821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001083598,"about_ca_system_score_gemma":0.00004481686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002309464,"about_ca_topic_score_gemma":0.000009740053,"domain_scores_codex":[0.9989299,0.00004710532,0.0002908223,0.000340098,0.0001252917,0.0002667625],"domain_scores_gemma":[0.9989572,0.0001124718,0.0001807481,0.0004879101,0.0001853273,0.00007639032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005779702,0.000111349,0.002945843,0.00008766238,0.0001194618,2.276891e-7,0.000301812,0.0005580765,0.9739946,0.0001153841,0.001445345,0.02026247],"study_design_scores_gemma":[0.0006154595,0.0007746618,0.004936395,0.00001241933,0.00005685202,4.818959e-7,0.0001192064,0.0015303,0.9709864,0.0009378868,0.01982613,0.0002038591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847412,0.009829758,0.003553678,0.0006505885,0.0001450032,0.0006009815,0.00005044431,0.000009457494,0.0004189359],"genre_scores_gemma":[0.989826,0.005058021,0.003011114,0.0001735309,0.0001400989,0.00006939044,0.00003147684,0.00003442313,0.001655899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02005861,"threshold_uncertainty_score":0.5718808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01246902512725807,"score_gpt":0.236104140352317,"score_spread":0.223635115225059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}