{"id":"W2003239720","doi":"10.1002/bies.201000033","title":"Returning to the stem state: Epigenetics of recapitulating pre‐differentiation chromatin structure","year":2010,"lang":"en","type":"review","venue":"BioEssays","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Reprogramming; Chromatin; Biology; Epigenetics; Induced pluripotent stem cell; Bivalent chromatin; Embryonic stem cell; Cell biology; Histone; Chromatin remodeling; Cellular differentiation; Stem cell; Epigenetic regulation of neurogenesis; DNA methylation; Genetics; Cell; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003331533,0.0006359211,0.0007801277,0.0008737505,0.0002313502,0.0007124858,0.0006796634,0.0009947864,0.001420785],"category_scores_gemma":[0.0003215821,0.0001879251,0.0002367461,0.0009974246,0.0007303958,0.00127672,0.0005378851,0.001338216,0.001573609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006389922,"about_ca_system_score_gemma":0.0004898896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007191645,"about_ca_topic_score_gemma":0.00117231,"domain_scores_codex":[0.9998941,0.00001955356,0.00001131635,0.000021156,0.00004419839,0.000009621587],"domain_scores_gemma":[0.9999027,0.00003683775,0.00001395776,0.00000691184,0.00002535088,0.00001418075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006169858,0.00004219251,0.0002575545,0.005898068,0.00005198813,0.0003124242,0.0001328684,0.0005840449,0.02246238,0.012673,0.01812941,0.9393944],"study_design_scores_gemma":[0.00001105862,0.00006555959,0.001188365,0.0007035191,0.00003959592,0.001521132,0.0001039844,0.0001677636,0.0060762,0.005799521,0.9843004,0.00002283514],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004379255,0.9953669,0.0009852049,0.0004954512,0.0003528074,0.000005322104,0.0000184498,0.00001922989,0.002318629],"genre_scores_gemma":[0.002151877,0.9951854,0.0005873651,0.000289995,0.0001996219,0.000008561162,0.00002835034,0.00000319824,0.00154563],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001420785,"threshold_uncertainty_score":0.004753053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02687104820258973,"score_gpt":0.3141023939793124,"score_spread":0.2872313457767227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}