{"id":"W2003301619","doi":"10.1371/journal.pone.0006518","title":"Limb Immobilization Induces a Coordinate Down-Regulation of Mitochondrial and Other Metabolic Pathways in Men and Women","year":2009,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":190,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Muscle atrophy; Atrophy; Cytochrome c oxidase; Biology; Mitochondrion; Internal medicine; Citrate synthase; Bioenergetics; Endocrinology; Muscle tissue; Gene expression; Protein turnover; Muscle biopsy; Metabolism; Protein degradation; Enzyme; Gene; Biochemistry; Skeletal muscle; Biopsy; Protein biosynthesis; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005523924,0.00006526817,0.0001280344,0.00003933422,0.00001929181,0.000004517384,0.00003181626,0.00009014169,0.000009775804],"category_scores_gemma":[0.00003556374,0.00006216835,0.00001026202,0.00005138316,0.00004513885,0.000004724168,0.00001870564,0.00002954955,3.555886e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002454166,"about_ca_system_score_gemma":0.00001174077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001210149,"about_ca_topic_score_gemma":0.000006677991,"domain_scores_codex":[0.9995576,0.00003952168,0.0001096086,0.0001538128,0.00004446183,0.00009498856],"domain_scores_gemma":[0.9998092,0.000006122507,0.00004949535,0.00008748707,0.00002203569,0.00002567165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002438445,0.0002537666,0.002055402,0.00001305445,0.0000313423,5.696478e-8,0.0003513914,0.000007091549,0.9956278,0.0002095225,0.000009158513,0.001197561],"study_design_scores_gemma":[0.001639991,0.0007190511,0.2150433,0.00002651623,0.00002750305,4.159253e-7,0.0002440768,0.0002044199,0.7785846,0.003281196,0.00007943044,0.0001494625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985437,0.0007006517,0.00001472493,0.000045817,0.000006859068,0.0001520866,0.000005220247,0.00000377026,0.0005272095],"genre_scores_gemma":[0.9994547,0.0001905867,0.0001459199,0.00009838752,0.00003930649,0.000016363,0.00001991706,0.000004629264,0.00003020547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2170432,"threshold_uncertainty_score":0.2535152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607643002012544,"score_gpt":0.2152742310822923,"score_spread":0.1991978010621669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}