{"id":"W2003331504","doi":"10.1152/ajpgi.00412.2010","title":"Hepatic stellate cells require a stiff environment for myofibroblastic differentiation","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Liver physiology and pathology","field":"Medicine","cited_by":349,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences","keywords":"Extracellular matrix; Hepatic stellate cell; Matrigel; Mesenchymal stem cell; Cell biology; Cellular differentiation; Myofibroblast; Fibrosis; Chemistry; Pathology; Biology; In vitro; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001788619,0.0003478878,0.001058186,0.0001795593,0.0001231891,0.000004093618,0.0001874283,0.00008224596,0.0002307292],"category_scores_gemma":[0.00006586861,0.0002642628,0.0002828341,0.00009824456,0.001385828,0.0001394875,0.0001071787,0.0004061943,0.0000294533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004248967,"about_ca_system_score_gemma":0.00008383713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003498729,"about_ca_topic_score_gemma":9.828952e-7,"domain_scores_codex":[0.9979939,0.0003073142,0.0006333654,0.0004473079,0.0001105234,0.0005075965],"domain_scores_gemma":[0.9979522,0.0004558481,0.0008984567,0.0002589422,0.0001859818,0.0002486094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004928067,0.0004694674,0.002305515,0.0001556738,0.0002189312,0.00003922772,0.0005814218,0.0000373099,0.9876854,0.0003892994,0.0000881134,0.003101569],"study_design_scores_gemma":[0.002923097,0.03628211,0.9335701,0.0002996006,0.0006615914,0.003320465,0.0004893106,0.0008445998,0.01458668,0.006432028,0.0002027813,0.0003876747],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959369,0.0001577895,0.003266882,0.00007375234,0.0001752606,0.0003012605,0.00002114849,0.00002090068,0.00004608845],"genre_scores_gemma":[0.9797598,0.0002044187,0.01918416,0.0003557802,0.0003544975,0.00001550841,0.00002214981,0.00003024708,0.00007340525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9730988,"threshold_uncertainty_score":0.999981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01738359565381582,"score_gpt":0.2190200312825224,"score_spread":0.2016364356287065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}