{"id":"W2003335852","doi":"10.1021/bi9013825","title":"Mechanistic Investigation of the Endo-α-<i>N</i>-acetylgalactosaminidase from <i>Streptococcus pneumoniae</i> R6","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Institute for Biological Sciences","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemistry; Glycan; Stereochemistry; Enzyme; Glycoside hydrolase; Disaccharide; Hydrolase; Biochemistry; Substrate (aquarium); Active site; Glycoprotein; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004720188,0.0005652581,0.000284036,0.00008521215,0.0001933719,0.0004884963,0.0006036113,0.0006631242,0.0005063014],"category_scores_gemma":[0.0002571412,0.0001808316,0.0003951227,0.0001043192,0.0004531347,0.0007560062,0.0003268521,0.0006979782,0.0002739932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005161503,"about_ca_system_score_gemma":0.0004789631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004593987,"about_ca_topic_score_gemma":0.0003777695,"domain_scores_codex":[0.9998052,0.00004305582,0.00001531766,0.00003262544,0.00006015021,0.00004365284],"domain_scores_gemma":[0.999889,0.00002170576,0.00003555794,0.00001277921,0.00002124919,0.00001978841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002829282,0.0001248875,0.001025972,0.0002070371,0.00002237925,0.0004550701,0.00006190923,0.002190707,0.9906033,0.00158563,0.00007478862,0.003365246],"study_design_scores_gemma":[0.00001413982,0.0002809461,0.001028789,0.000007116379,0.00001279023,0.0005924113,0.00007506025,0.003956046,0.9921704,0.0004043457,0.001446946,0.00001109718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888738,0.001276628,0.006896762,0.0002613911,0.00002327282,0.00005495372,0.0001716553,0.00003664658,0.002404926],"genre_scores_gemma":[0.9933434,0.001210901,0.004263819,0.00006064817,0.000004286353,0.00002867487,0.0001717486,0.000008898484,0.0009076592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006631242,"threshold_uncertainty_score":0.0037449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005689644131627057,"score_gpt":0.2016035226593726,"score_spread":0.1959138785277456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}